Sentences with phrase «abnormal human gene»

They have demonstrated that, in some embryos, but not all, they can change the abnormal human gene.

Not exact matches

The scientists looked for mutations, or abnormal changes in the DNA, and filtered out normal variations in genes that commonly occur among humans.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

The offspring of monkeys carrying human genes associated with autismlike symptoms had abnormal social behavior, researchers found.

Junjiu Huang and colleagues at Sun Yat - sen University in Guangzhou describe their efforts to use the CRISPR - Cas9 gene - editing technology to alter a gene in abnormal human embryos.

Mice that lack the fmr1 gene (and therefore lack the FMRP protein) show some of the same symptoms of human FXS, including seizures, impaired sleep, abnormal social relationships, and learning defects.

To look further into this issue, the CUMC researchers developed a novel transgenic mouse in which the gene for abnormal human tau is expressed predominantly in the entorhinal cortex.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

These genes likely came from the gametes — the eggs or sperm — and can be used to predict whether an embryo is chromosomally normal or abnormal at the earliest stage of human development.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??