Sentences with phrase «abnormal huntingtin»

In HD animal models, clearing away abnormal huntingtin deposits has led to improvements in symptoms, and Alfy plays an important role in cleanup.

Things go awry when these fragments are drawn toward the globs of abnormal huntingtin, instead of being processed further.

Zeitlin says the study may also help researchers find new targets for drugs against Huntington's — such as compounds that block the clumping of abnormal huntingtin.

Not exact matches

This abnormal binding causes more VCP accumulation on the mitochondria,» Nerve cells with VCP - mutant huntingtin interacting inside them became dysfunctional and self - destructed.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

When caspases chopped off small peptides from the mutant region of huntingtin, they thought, the peptides accumulated into the abnormal globs seen in the neurons of Huntington's victims.

Huntington's disease is caused by the abnormal repetition of a specific DNA sequence at the tail end of the huntingtin gene.

The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate - forming protein «huntingtin» of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway.

R6 / 2 mice have been genetically altered with an abnormal gene that makes them produce a harmful fragment of the mutant huntingtin protein

The mutation causing HD is an abnormal polyglutamine stretch in huntingtin.

Huntington's Disease (HD) is an autosomal dominant inherited disease characterized by an abnormal and unstable expansion in the number of CAG trinucleotide repeats in exon 1 of the huntingtin gene (Group HsDCR, 1993).