Sentences with phrase «abnormal increase in»

Canine Thyroid Disease Example of Hyperplastic thyroid (abnormal increase in the number of normal cells) from an iodine - deficient dog Source: Washington State University

The result can be necrosis (cell death caused by degradation), hyperplasia (abnormal increase in normal cells) and hemorrhage (bleeding).

In looking at telomere length, an abnormal increase in telomere loss can tell us there may possibly be an immunoproliferative disorder (the inability to handle oxidative stressors), metabolic abnormalcy, or progressive chronic disease that is present.

Irritation and inflammation of the intestinal mucosa may occur, leading to an abnormal increase in intestinal permeability or «leaky gut.»

As it progresses, there I an abnormal increase in the white blood cells and this type of cancer is often diagnosed in older people while this is rare for people below age 45.

Importantly, this results in an abnormal increase in centrosome number, a 10-fold reduction in the numbers of satellite stem cells undergoing asymmetric divisions, and a marked decrease in the generation of myogenin - expressing progenitors.

A storm surge is an abnormal increase in the local sea level.

Having n abnormal increase in «fear hormones» can interfere with the birth process.

Females entered puberty at earlier ages, and both sexes showed an abnormal increase in their growth rate.

Abnormal increases in estradiol can lead to mood swings, breast tissue changes, and fluid retention that may cause swelling or increases in blood pressure.

Princeton researchers also state: «In addition to causing significant weight gain in lab animals, long - term consumption of high - fructose corn syrup also led to abnormal increases in body fat, especially in the abdomen, and a rise in circulating blood fats called triglycerides».

Moreover, a long - term diet of HFCS led to abnormal increases in body fat and rising amounts of blood fats (triglycerides).

Not exact matches

(She notes since introducing the mammogram, there has been a five-fold increase in Stage Zero breast cancer, a condition in which abnormal cells are found — but are not actively spreading — in the breast.)

This increase in abnormal test results can have negative consequences for medicine in the form of extra testing, additional patient visits to clinics / hospitals, and added doctor services, all of which result in additional costs and burdens to patients or to the healthcare system and are potentially harmful.

Using a differences - in - differences methodology, we find that politically active firms saw an increase in their stock's volatility along with negative long - term abnormal stock returns upon the release of the NCR.

This grain - based diet can cause changes in the ph in cows, creating many abnormal physiological conditions in the cow which can increase the need for the use antibiotics.

Whey protein may cause abnormal heart rhythms, changes in cholesterol levels, headache, increased diabetes risk, increased fracture or osteoporosis risk, kidney dysfunction, liver damage, stomach or intestine symptoms (acid reflux, bloating, constipation, cramps, gas, increased bowel movements, movement problems, nausea, reduced appetite, swelling of limbs, and upset stomach), and thirst.

In APL, immature white blood cells called promyelocytes increase in abnormal numbers and accumulate in the bone marroIn APL, immature white blood cells called promyelocytes increase in abnormal numbers and accumulate in the bone marroin abnormal numbers and accumulate in the bone marroin the bone marrow.

She found that milestone achievement was abnormal in these monkeys: at six to eight weeks they were slow in starting to manipulate, and at ten months the increase in «motor disturbance behaviors» that normally occurs was prolonged.101 The author concludes, «These effects could occur as a result of effects on vulnerable brain processes during a sensitive period, interference with programming of [normal] brain development by endogenous [internal] agents or alteration in early experiences.»

Referrals to craniofacial centers for evaluation of deformational plagiocephaly and brachycephaly are increasing.8 This increase in deformations has been temporally linked to the Back to Sleep program advanced by the American Academy of Pediatrics in 1992 that advises the avoidance of the prone sleeping position as a method of reducing the rates of sudden infant death syndrome.10,, 12,13 There is a delay in early gross motor milestones in children forced to sleep supine but these delays seem transient and have not been linked as yet to any longer term problems.14 Children who are encouraged to sleep on their backs and develop abnormal head shapes as a result are a different population than children who spontaneously restricted their movement in bed for one reason or another.

When there is an increase in blood circulation at the time of pregnancy, the blood vessels may branch outwards and appear abnormal.

In any patient, the Cesarean section rate for twins is MUCH higher than for singletons, secondary to increased rates of need for induction and abnormal presentation.

In 2004, Looy and her former Ph.D. advisor Henk Visscher proposed one way this might have played out, bases on fossilized abnormal plant spores found worldwide: volcanic gases — halocarbons like methyl chloride and methyl bromide — destroyed much or all of Earth's ozone layer, boosting UV - B exposure that would have affected life and potentially increased the genetic mutation rates in pollen and spores of plants worldwidIn 2004, Looy and her former Ph.D. advisor Henk Visscher proposed one way this might have played out, bases on fossilized abnormal plant spores found worldwide: volcanic gases — halocarbons like methyl chloride and methyl bromide — destroyed much or all of Earth's ozone layer, boosting UV - B exposure that would have affected life and potentially increased the genetic mutation rates in pollen and spores of plants worldwidin pollen and spores of plants worldwide.

The researchers found that HAND2 methylation is already increased in premalignant endometrial lesions (cancer - prone, abnormal - looking tissue) compared to normal endometrium, and that a high level of methylation predicted a poor response to progesterone treatment (which stops the growth of some pre-cancerous endometrial lesions).

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

Abnormal color vision increases significantly with aging — affecting one - half or more of people in the oldest age groups, reports a study in Optometry and Vision Science, official journal of the American Academy of Optometry.

While late - term gestation was associated with an increase in the rate of abnormal conditions at birth and with worse physical outcomes during childhood, it was also associated with better performance on all three measures of school - based cognitive functioning measures during childhood,» the study concludes.

The report indicates that Sestrin 3 plays a critical role in regulating molecular pathways that control the production of glucose and insulin sensitivity in the liver, making it a logical target for drug development for type 2 diabetes and metabolic syndrome, which can produce increased blood pressure, abnormal cholesterol levels and insulin resistance.

«Children or young adults may not be aware of having abnormal coronary vessels because their circulation is adequate until the heart is stressed by increased demands, for instance when participating in strenuous sports,» explains Lien, who is also an assistant professor at the Keck School of Medicine and an investigator at the Cardiovascular Thoracic Institute, both at the University of Southern California.

Cumulative abnormal returns increase with risk in the United States, but they decrease with risk in Western Europe.

Second, the mice also showed dramatic increases in brief (lasting 2 - 3 seconds) bouts of abnormal brain wave activity.

Previous studies have shown that this forebrain - midbrain circuit is abnormal in panic and chronic anxiety patients who show decreased vmPFC but increased gray matter volume and activity in the midbrain encompassing the PAG (24, 25).

Both groups that received andro showed significant increases in estradiol — a potent female hormone that causes abnormal breast development in men.

The most accredited hypothesis to explain these abnormal cases invokes collision and merging between two galaxies: these outliers would therefore be nothing but galaxies captured during their collision, a phenomenon that would lead to a sudden, though transient, increase in their star formation rate.

February 2, 2006 Gene variation increases SIDS risk in African Americans About five percent of deaths from SIDS (sudden infant death syndrome) in African Americans can be traced to defects in one gene, and half of those deaths result from a common genetic variation that increases an infant's risk of developing an abnormal heart rhythm during times of environmental stress, a research team based at the University of Chicago reports in the February 2006, issue of the Journal of Clinical Investigation.

The attenuation of MP's effects could also reflect abnormal D2 receptor function, as was previously suggested to explain findings in marijuana - abusing schizophrenic patients, who, despite displaying low DA release, showed increases in psychotic symptoms when challenged with amphetamine (21).

In cancer cells, the drugs produce a substantial increase in the display of abnormal proteins on the cells» surfacIn cancer cells, the drugs produce a substantial increase in the display of abnormal proteins on the cells» surfacin the display of abnormal proteins on the cells» surface.

The elevated incidence of glomerulonephritis in p21 - deficient mice, with increased severity among females, has been reported previously (35) and is attributable to an autoimmune process produced by abnormal proliferation of memory T - cell lymphocytes.

In diabetic rat models, female mesenteric arteries show greater abnormal vascular responses demonstrated by greater impairment of acetycholin - induced relaxation and an increased expression of endothelial nitric oxide synthase.

However, it is widely accepted that a central event in AD pathogenesis is the abnormal accumulation of Aβ and its related toxins, either due to increased production or to deficits in clearance mechanisms [52, 53].

We report here that in vitro generated DS neural cells have abnormal metabolism of amyloid - β (Aβ) manifested by increased secretion and accumulation of Aβ granules of Aβ42 pathological isoform with upregulated expression of the APP gene.

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Increasing the amount of either miR - 142 or miR - 150 causes excessive cell growth in breast tissue and can form abnormal breast tissue in mice.

About 40 percent of Americans have calcified pineals by age seventeen.50 «Calcium, phosphorus and fluoride deposits increase with aging and are likely to cause decreased melatonin production and abnormal pineal function, which could contribute to a variety of effects in humans.»

In test animals, diets high in polyunsaturates from vegetable oils inhibit the ability to learn, especially under conditions of stress; are toxic to the liver; compromise the integrity of the immune system; depress the mental and physical growth of infants; increase levels of uric acid in the blood; cause abnormal fatty acid profiles in the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aginIn test animals, diets high in polyunsaturates from vegetable oils inhibit the ability to learn, especially under conditions of stress; are toxic to the liver; compromise the integrity of the immune system; depress the mental and physical growth of infants; increase levels of uric acid in the blood; cause abnormal fatty acid profiles in the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aginin polyunsaturates from vegetable oils inhibit the ability to learn, especially under conditions of stress; are toxic to the liver; compromise the integrity of the immune system; depress the mental and physical growth of infants; increase levels of uric acid in the blood; cause abnormal fatty acid profiles in the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aginin the blood; cause abnormal fatty acid profiles in the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aginin the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aging.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

He found abnormal glucose tolerance in subjects with antisocial personality and increased insulin secretion with excessive sugary foods, especially with alcoholics.98 He confirmed the fact that violent male homicidal offenders had much lower cholesterol levels than other offenders; and that impulsive violent offenders and fire setters have low serotonin levels in the brain.

Studies suggest that flax may reduce the growth of abnormal cells and increase apoptosis (programmed death) of cancer cells in breast tissue (1, 2, 3).

«In our modern world where people are regularly taking antibiotics and other pharmaceutical drugs, where food is laced with chemicals alien to the human physiology, an increasing number of people have damaged, abnormal gut flora dominated by pathogenic [disease - causing] microbes.

Evidence indicates that increased iodine consumption replaces and therefore helps detox other halogens, such as fluoride and bromide, and even toxic metals like lead, aluminum and mercury.11 One theory is that liberal amounts of iodine in the diet can protect against the harmful effects of fluoridated water.12 Iodine supports the immune system and protects against abnormal growth of bacteria in the stomach.13