Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of
abnormal tumor stem cell differentiation (9).
Also limiting the use of therapeutic
stem cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source of cancer risk when haphazard, unlimited
cell multiplication results in the
abnormal tissue growth seen in
tumors.