Sentences with phrase «abnormalities in»

Our pathologists, doctors who use microscopes to look for abnormalities in cells or tissue removed through a biopsy, are responsible for the initial evaluations involved in a cancer diagnosis.

Abnormalities in a gene called FLT3 (pronounced flit - 3) are common among patients with acute myeloid leukemia.

Neural markers of familial risk for depression: An investigation of cortical thickness abnormalities in healthy adolescent daughters of mothers with recurrent depression.

Gray Matter Abnormalities in Non-comorbid Medication - naive Patients with Major Depressive Disorder or Social Anxiety Disorder

Abnormalities in heartbeat synchronization, called heart arrhythmias, are a cause of death for the 5.7 million Americans who suffer from heart failure, a condition in which the heart can't pump enough blood to meet the body's needs.

Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders

Dr. Mucke has spent most of his career uncovering the molecular and cellular mechanisms that cause memory loss and behavioral abnormalities in Alzheimer's disease and related conditions.

The study of cancer genomes has revealed abnormalities in genes that drive the development and growth of many types of cancer.

A dual yeast and human stem cell discovery platform for Parkinson's disease: Investigations in simple baker's yeast cells brought to light abnormalities in Parkinson's patient neurons and identified genes and small molecules that correct them.

Abnormalities in mitochondrial genes, gene expression and gene function in inherited and complex diseases, like neuromuscular disorders, neurological syndromes and cardiomyopathies, in human patients and animal models, but alos in therapy - predictions (radiotherapy).

To help plug this diagnostic hole, Rebecca is leading the OCCAMS trial, a CRUK - funded multicentre study which is part of the International Cancer Genome Consortium (ICGC) global project to generate a comprehensive catalogue of genomic abnormalities in 50 tumour types.

Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.

Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis.

Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse RetinaRPE Abnormalities in Diabetic Nyxnob Mice.

The scientists noticed several abnormalities in the heart cells created from the patients: the cells beat weaker than normal, and numerous genes in the cells were abnormally activated or silenced.

The study, «Frontolimbic Morphometric Abnormalities in Intermittent Explosive Disorder and Aggression,» was supported by the National Institute of Mental Health.

This is controversial, since the amount of benefit in those patients without either abnormalities in the pathway or in the homologous recombination defect assay are really quite modest, and whether this warrants the toxicity of the PARP inhibitors in these circumstances will require additional study.

Indeed, at least in part, the abnormalities in homologous recombination deficiency have contributed to the very outstanding responses to platinum therapy and very striking new data with PARP (poly [ADP - ribose] polymerase) inhibitors.

(In submission) Obsessive - compulsive disorder (OCD) is a severe psychiatric disorder linked to abnormalities in the cortico - striatal circuit and glutamate signaling.

After colleagues at Sanofi provided an investigational compound that activates PKM2, the team showed that this compound could stop abnormalities in mouse podocytes both in cell culture and in two mouse models of diabetes.

The genetic defect causing skeletal abnormalities in Shetland ponies has been identified by researchers at Uppsala University and Swedish University of Agricultural Sciences (SLU).

In fact research today points to the fact that chronic, low - grade abnormalities in immune system response set the stage for chronic diseases in general, including OA.

Macrophages from lupus - prone MRL mice are characterized by abnormalities in Rho activity, cytoskeletal organization, and adhesiveness to extracellular matrix proteins.

«In Australia, for instance, the incidence of genital warts and precancerous cervical abnormalities in young women is plummeting.»

Protein profiles in the Dp (10) 1Yey and Dp (17) 1Yey mice predict novel pathway perturbations in the Down syndrome brain and sex - specific abnormalities in protein levels

The researchers found a link between abnormalities in white matter and a decrease in functional connectivity in the brain's default - mode network, a set of regions that typically shows abnormal behavior in people at genetic risk for Alzheimer's disease.

Oakeshott S, Balci F, Filippov I, Murphy C, Port R, Connor D, Paintdakhi A, Lesauter J, Menalled L, Ramboz S, Kwak S, Howland D, Silver R, Brunner D. Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.

Dodero, L., Damiano, M., Galbusera, A. Bifone, A., Tsaftsaris, S.A., Scattoni, M.L., Gozzi, A * Neuroimaging Evidence of Major Morpho - Anatomical and Functional Abnormalities in the BTBR T+TF / J Mouse Model of Autism.

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

C Ramirez - Renteria and colleagues conduct a study to evaluate the molecular abnormalities in the AIP gene in a cohort of Mexican patients with acromegaly with disease onset before the age of 30.

White matter fibers connect the different areas of the brain and abnormalities in white matter may be tied to the development of dementia and other cognitive disorders.

Interestingly, Nav1.1 - deficient interneuron transplants were sufficient to cause behavioral abnormalities in wild - type mice, indicating the key functional role of interneurons and Nav1.1 for cognitive functions.

Abnormalities in brain regions involved in forming insight may help explain why some people with anorexia nervosa have trouble recognizing their dangerous, dysfunctional eating habits.

«Studies of fetuses and babies with the telltale small brains and heads of microcephaly in Zika - affected areas have found abnormalities in the cortex, and Zika virus has been found in the fetal tissue,» says Guo - li Ming, M.D., Ph.D., a professor of neurology, neuroscience, and psychiatry and behavioral science at Johns Hopkins» Institute for Cell Engineering.

Understanding the biochemical processes that are important for maintaining these connections may help address the abnormalities in nerve cells that occur in these disease states.

Next, we investigated whether injection of pure, synthetic IAPP aggregates was able to induce IAPP deposition and associated diabetic abnormalities in vivo.

There appears to be a connection between the OCD symptoms and abnormalities in certain areas of the brain, but that connection is not clear.

Male sterility in mice lacking retinoic acid receptor α involves specific abnormalities in spermiogenesis

Recent research has found that babies who die of sudden infant death syndrome may have abnormalities in the part of the brain that helps control functions like breathing, blood pressure and arousal.

The discovery could also be used to create algorithms that detect abnormalities in behaviour.

To investigate the presence of IAPP accumulation and gross morphological abnormalities in nonpancreatic tissues, a section from the tissue was randomly chosen, and every tenth section was assessed (with a distance of 50 µm among them).

Our analysis revealed no gross morphological abnormalities in the groups treated with IAPP aggregate - containing material, compared with buffer - treated controls (Fig. 8 D).

Participants with body dysmorphic disorder showed similar but weaker abnormalities in the same regions.

Multivariate analysis was used to identify the pattern of chemical abnormalities in CFS compared with healthy controls.

Antipsychotic medications, a mainstay of treatment for schizophrenia, alleviated some of the animals» symptoms.In the new study, Soderling, postdoctoral researcher Il Hwan Kim, and their team characterized three brain abnormalities in the Arp2 / 3 mice that also appear in people with schizophrenia.

Diffusion tensor imaging is the first imaging technique that shows abnormalities in the brain's white matter after concussion.

That's because the compounds have been used to treat peptic ulcers, and there is no indication of finger abnormalities in these patients, he notes.

Investigators at the Cedars - Sinai Regenerative Medicine Institute have identified new molecular abnormalities in the diabetic cornea that could contribute to eye problems in affected patients.

Abnormalities in the thyroid are associated with an assortment of diseases, including autoimmune thyroid diseases, such as Grave's disease and Hashimoto's disease.

According to neurologists R. John Leigh and David Zee, authors of the comprehensive The Neurology of Eye Movements (Oxford University Press, 1999), schizophrenics show consistent abnormalities in the voluntary control of saccades, particularly in tasks requiring imagination, memory or prediction.