«We still know so little
about brain diseases that it will take a while before we can confidently develop analytic models of such complex biology,» she says.
Not exact matches
Dr. Stanley Crooke Ionis President discusses why he is optimistic
about the deal between Biogen and Ionis to fight
brain disease.
The girl, who experienced a stroke and then subsequent
brain damage from the
disease and now takes a Horizon medicine to stabilize the condition, spoke
about how happy she was that country singer Chris Jacobs wrote a song for her.
Of course, I was * probably * stressed
about other things, such as packing, college applications, etc. and my silly
brain decided to focus on mosquitos and
diseases instead.
When I joined internet forums
about coeliac
disease, I noticed the term «
brain fog» floating around, and saw that I was far from the only one experiencing these symptoms.
I worry that lost amidst the hoopla
about the new CTE study is the fact that not every football player whose
brain was donated to the CTE Center for pathological scrutiny was found to have the
disease, and, that it was not detected in either the
brains donated by the families of football players who died before they got to high school, and in only three of fourteen of high school players (and, in those, the
disease had not progressed beyond the «mild» stage).
Research suggests that
about a third of kids are lucky enough to escape trauma, but
about a quarter suffer such high doses that it affects
brain development, immune and endocrine functioning, and can create mental and physical
disease systems that reduce the lifespan by an average of 20 years.
«a
disease process in the
brain, involving the cortical neurones, brought
about by an autointoxication... as a result of a disorder of metabolism.»
Instead, the new version limits its use to
about 20 serious conditions, including cancer, traumatic
brain injury, AIDS, Parkinson's
Disease, multiple sclerosis and post - traumatic stress disorder.
These current studies represent a leap forward in the knowledge base
about HS - AGING, and represent potential new paths to explore for diagnosis and treatment of this serious, but under - appreciated
brain disease.
[June 23, 2012] As scientists continue to make advances in neuroscience, they are learning more
about how the aging
brain functions in health and
disease.
«While electrical stimulation of the
brain is emerging as potential therapy for a wide range of neurological and psychiatric
diseases, little is known
about its effect on memory,» says Gregory Worrell, M.D., Ph.D., a Mayo Clinic neurologist and senior author of the article.
HARD KNOCKS By studying the
brains of former football players, researchers are finding clues
about how a neurodegenerative
disease called chronic traumatic encephalopathy, or CTE, progresses, with the hopes of one day preventing it.
Advances in neuroscience have enabled researchers to learn more
about how the adolescent
brain functions, from the everyday behavior of teenagers to how they cope with the challenges of
disease, learning problems, and social cues.
In the meantime, those with AB blood need not panic
about their future cognitive wherewithal, she says, noting that all our
brains are apt to benefit from a healthy diet, awareness of our risk factors for heart
disease and stroke, and regular exercise for the body and
brain.
«The fact that a [cell] culture expresses most genes present in the
brain says nothing
about its appropriateness as a
disease model,» says Knoblich.
Svendsen is more optimistic
about his team's work involving human tests of a novel stem cell approach to treat ALS, a degenerative motor neuron
disease in which cells that transmit messages from the
brain and spinal cord to the muscles wither or die.
Stanford University researchers studying how the
brain controls movement in people with paralysis, related to their diagnosis of Lou Gehrig's
disease, have found that groups of neurons work together, firing in complex rhythms to signal muscles
about when and where to move.
The nationally representative survey of more than 4,700 U.S. adults centered on public views
about: gene editing that might give babies a lifetime with much reduced risk of serious
disease, implantation of
brain chips that potentially could give people a much improved ability to concentrate and process information, and transfusions of synthetic blood that might give people much greater speed, strength and stamina.
Understanding more
about the process could help prevent the onset of degenerative
brain diseases.
But recent technological advances and a series of remarkable discoveries in the past two years have provided key clues
about how Alzheimer's
disease ravages the
brain.
The scientists transferred the twins» gut bacteria to mice predisposed to develop a
disease that mimics MS. Twelve weeks after the transplant,
about 40 percent more mice with gut microbes from a twin with MS developed
brain inflammation compared with mice that got gut microbes from a twin without
disease.
A new discovery
about the immune system may allow doctors to treat harmful inflammation that damages the
brain in neurodegenerative
diseases such as Alzheimer's.
After taking a close look at autopsiedhuman
brains, scientists at the Buck Institute in Novato, California, foundthat those with Alzheimer's
disease had
about ten times as much cleavage inthe
brain, a process that Dale Bredesen, Buck Institute founder andleader of the research group describes as «molecular scissors» cutting out the amyloid - beta protein.
«One of the things we know
about Alzheimer's
disease is that this region of the
brain is one of the very first to exhibit a key hallmark of the
disease, deposition of neurofibrillary tangles.»
«If you look at the «normal»
brains that come into the bank,
about 15 per cent actually aren't normal — they've got early stages of a neurodegenerative
disease.»
Alzheimer's
disease can be diagnosed at a glance from
brain shrinkage of
about 10 percent.
It may also bring
about advances in diagnosing
diseases like Alzheimer's and multiple sclerosis, both of which involve abnormal iron accumulation in the
brain.
The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both
about the workings of the
brain and the
diseases that plague it.
Muotri noted that the research represents one of the first efforts to use iPSCs and
brain in - a-dish technology to generate novel insights
about a
disease process and not simply replicate data from other models.
«With this study, we have gained new knowledge
about the
disease processes in the
brain in the early initial stages of the
disease development.
For example, how genetic programs affect the function of specific cell types, how they vary early or later in life and how dysfunction in these programs might contribute to
disease, all of which could help scientists learn more
about the fundamental workings of the
brain.
«This research provides new insight
about the potentially harmful effects of a lack of sleep on the
brain and has implications for better characterizing the pathology of Alzheimer's
disease,» said George F. Koob, Ph.D., director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, which funded the study.
Parkinson's
disease is caused by loss of the
brain signaling chemical dopamine and affects
about 1 million people in the United States.
Extracts from the
brains of FFI patients transmitted
disease to transgenic mice expressing a chimeric human - mouse PrP gene
about 200 days after inoculation and induced formation of the 19 - kilodalton PrPSc fragment, whereas extracts from the
brains of familial and sporadic Creutzfeldt - Jakob
disease patients produced the 21 - kilodalton PrPSc fragment in these mice.
Researchers have long known that in
about half of FTD cases,
brains are speckled with protein clumps containing tau, a protein implicated in Alzheimer's and other
brain diseases.
A surprise discovery that overturns decades of thinking
about how the body fixes proteins that come unraveled greatly expands opportunities for therapies to prevent
diseases such as Alzheimer's and Parkinson's, which have been linked to the accumulation of improperly folded proteins in the
brain.
Our investigations also open a new route for understanding how different physiological states of the body influence stem cells in the
brain during health and
disease, and opens new ways for thinking
about therapy,» says Fiona Doetsch.
A new study casts doubts on a long - held theory
about what goes awry in the
brains of patients with Huntington's
disease.
«A lot of work that initiated this project stemmed from what we learned
about how these pathways work in normal
brain development, and as we learn more
about how it normally works we think it'll provide us with novel insight
about how to target it in
disease.»
He and his team hope to learn more
about the impact of exercise on
brain function and whether it could delay the onset or progression of Alzheimer's
disease.
Our research suggests that we may also need to think
about targeting the
brain to treat non-alcoholic fatty liver
disease.»
He thought
about a previous patient, a battered woman whose autopsy had shown signs of
brain disease.
Scientists at the Montreal Neurological Institute and Hospital - The Neuro, McGill University, have made important discoveries
about a cellular process that occurs during normal
brain development and may play an important role in neurodegenerative
diseases.
In a paper published in Nature Communications, scientists at the Institute for Research in Biomedicine (IRB Barcelona) provide molecular details
about Seckel Syndrome, a rare
disease that causes microcephaly, or small
brain, and growth delays.
About Kessler Institute for Rehabilitation Kessler Institute for Rehabilitation is nationally recognized for the treatment and research of both spinal cord and
brain injuries and also leads the field in the care and treatment for stroke, neurological
diseases, amputation, orthopedic and musculoskeletal conditions and cardiac recovery.
In the lab, protein amyloids, like those that clog up the
brains of people who died from Alzheimer's
disease, are impervious to just
about anything, including extreme heat and cold and powerful detergents.
What we are learning from these studies adds important knowledge
about the human
brain in both health and
disease.
In the PNAS paper, Varvel and his colleagues include a cautionary note
about using these mice for studying situations of more prolonged
brain inflammation, such as neurodegenerative
diseases: the monocytes may turn down production of the red protein over time, so it's hard to tell if they're still in the
brain after several days.
About Kessler Institute Kessler Institute for Rehabilitation, a division of Select Medical, provides comprehensive care and specialized treatment to address the complex needs of individuals with spinal cord injury,
brain injury, stroke, amputation, neurological
diseases, cardiac recovery and orthopedic / musculoskeletal conditions.