PD - 1 was clearly the most talked -
about molecule at the conference, prompting one scientist to confess, «I feel like an exhausted T cell.»
Not exact matches
The side effect was first observed earlier this month
at the American Society of Hematology conference, where CEODavid Schenkein spoke with CNBC
about the safety of one of the
molecules in its drug, which was meant to treat pyruvate kinase deficiency, a rare, genetic anemia.
At the present time, the concentration is
about 390 ppm, 0.039 percent of all atmospheric
molecules and less than 1 percent of that in our breath.
Since a protein
molecule can have anywhere from as few as 50 or as many as several thousand amino acids bound together in a highly specific order, what are the odds of say, a protein with 100 amino acids coming
about at random?
Oh, the Calvinists could make perfect sense of it all with a wave of a hand and a swift, confident explanation
about how Zarmina had been born in sin and likely predestined to spend eternity in hell to the glory of an angry God (they called her a «vessel of destruction»);
about how I should just be thankful to be spared the same fate since it's what I deserve anyway;
about how the Asian tsunami was just another one of God's temper tantrums sent to remind us all of His rage
at our sin;
about how I need not worry because «there is not one maverick
molecule in the universe» so every hurricane, every earthquake, every war, every execution, every transaction in the slave trade, every rape of a child is part of God's sovereign plan, even God's idea;
about how my objections to this paradigm represented unrepentant pride and a capitulation to humanism that placed too much inherent value on my fellow human beings;
about how my intuitive sense of love and morality and right and wrong is so corrupted by my sin nature I can not trust it.
At present, we have quite detailed knowledge
about molecules, ions, atoms, elementary particles, electromagnetic waves, electric fields and all kinds of material processes, but we are still not yet able to say what «matter» ultimately is like.
And here are the physicists, splitting up the
molecule into atoms and now picking away
at the atom itself, peering down into the deep abyss in which the constituent elements of all chemical things are the same; yet never a word have they to tell us
about where «form» ends and «matter» begins!»
Rather, before we make hasty, uninformed guesses
about things as enormously complicated as whole organs and animals, we must first look
at life's foundation»
molecules and cells» to see what natural selection can explain there.
Every breath we take includes
about a billion oxygen
molecules that have been,
at one time or another, in the lungs of every one of the fifty billion humans who have ever lived.
As I wrote in an article
about Christmas cookies for Edible Seattle magazine last year, once my maternal grandparents had frozen an adequate amount of lefse for the holidays and cleaned away any
molecules of errant flour that had crept beyond the plastic sheets, they could relax (a bit
at least) and begin baking cookies.
Looking
at the size of the
molecule I still wonder
about the topical route of administration being particularly effective.
«We are very excited
about the prospect of using these more physiologically relevant cell - based models for gene and small
molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology
at the University of Memphis.
Lawrence Goldstein and his colleagues
at the University of California, San Diego (UCSD), reasoned that if they could find a
molecule that halts kinesin function, they could learn more
about when and how they work — and possibly design drugs to disable specific kinesins.
«Several lead
molecules for prospective clinical use have been identified through our collaboration with Dr. Kenneth Jacobson
at the National Institutes of Health and we are very excited
about the potential for translational therapeutic impact,» Salvemini said.
«Generally, most existing techniques to look
at single -
molecule movements — such as optical tweezers — have a resolution,
at best, of
about 300 picometers,» said Gundlach.
It is
about focusing on the pipeline, the science, and our people, and building quality into our
molecules at the source.»
Kourosh Kalantar - Zadeh, an engineer
at the Royal Melbourne Institute of Technology in Australia, and his colleagues built plastic capsules
about 2.5 centimeters long —
about as long as a Jolly Rancher hard candy — that sniff out carbon dioxide, hydrogen and oxygen gas
molecules in the gut.
Zemer Gitai, a microbiologist
at Princeton, remembers talking with Huang and Wingreen
about a question that microbiologists were stuck on: How are
molecules oriented in bacterial cell walls?
On Titan the photochemistry starts
at the top of the atmosphere,
about 1000 kilometres up, where energetic ultraviolet photons from the sun and cosmic rays trigger reactions among methane and nitrogen
molecules.
It's a way to think
about the CO2 going into the ocean from the atmosphere, going from the atmosphere back up into the ocean; so I start Dave off
at the beginning of the book in a
molecule of alcohol, in a glass of beer, that's where Dave is starting off.
At room temperature, they observed an on / off ratio of
about 600 in single - cluster junctions, higher than any other single -
molecule devices measured to date.
But, says Michael Varney, head of the small
molecule drug discovery group
at Genentech, those hiring trends are
about to change: «For us, over the next 3 years, we'll hire more medicinal chemists and more process and scale - up chemists than we will analytical chemists.»
The simple Stokes - Einstein relationship is based on arguments
about how
molecules move randomly
at the microscopic level.
At its most basic, synthetic biology is
about making DNA from scratch, on scales from individual
molecules to cells, tissues and even entire organisms.
Some neat things
about a SAM are that (1) the SAM sways around like a liquid even though it's attached to a solid anchor
at one end and (2) it's possible to link different kinds of
molecules to it.
Physicists
at JILA have made their «quantum crystal» of ultracold
molecules more valuable than ever by packing
about five times more
molecules into it.
The latest example of their skill is a propeller fashioned from a single
molecule (see image
at right) that spins
about 100 million times a second, a device that promises to be far more practical than their abacus.
That's why we started thinking
about looking
at other
molecules that could have some effect in killing such antibiotic resistant bacteria.»
«It's hard to say that what you see in one system can be translated to another system because you are talking
about different
molecules, and each one has to be processed according to the functionality you want
at the end.»
With blistering temps hovering
at about 4,300 o Celsius, the atmosphere on KELT 9b's dayside is over 700 degrees hotter than the previous record - holder — and hot enough that atoms can not bind together to form
molecules.
Made out of a mere five
molecules, the Ohio Bobcat Nanowagon checks in
at 3.5 nanometers long and 2.5 wide —
about the width of a DNA strand.
Many people think if that is as kind of silly or just game playing, but it turns out that these ideas are
at the roots, these ideas
about self - reference are also
at the roots of the self - reproduction and are
at the roots of how living beings reproduce themselves; because the same mechanism of self - reference has to be used in order for an object, the machine or a
molecule, to reproduce itself.
The science team, led by chemist Brett McGuire
at the National Radio Astronomy Observatory (NRAO) in Charlottesville, Virginia, detected this
molecule's telltale radio signature coming from a nearby star - forming nebula known as the Taurus Molecular Cloud 1 (TCM - 1), which is
about 430 light - years from Earth.
An examination of millions of studies of
molecules that play a role in biological function reveals that «scientists in this field were
about 10-fold less efficient [
at making new discoveries] than they could have been,» one of the paper's co-authors, computational biologist Andrey Rzhetsky of the University of Chicago (UC) in Illinois, told our colleague John Bohannon on publication day.
But then in October, independent teams of researchers in Kyoto and
at MIT successfully applied Fujita's protocol to other
molecules, drumming up excitement all over again
about the potential Fujita's work holds for future applications.
«We don't know much
about pleiotropy, or how it happens, or how it's regulated
at the level of the
molecules.
Hans Røy, a geomicrobiologist
at Aarhus University, found that each cell uses
about one oxygen
molecule per second — roughly one hundred - thousandth the metabolic rate of typical surface bacteria.
«If you want to look
at what brought
about these properties of life you have to go back and consider all the other
molecules that would have been present and see how they would have facilitated the
molecules that are present in life today,» Krishnamurthy said.
«Because we can see individual macromolecules moving
about in a living cell, we can study chemistry
at a single -
molecule level and in real life.
«We may not even know what we should be looking for in these asteroids, but by looking
at what
molecules we find, we can ask different and more questions
about how they could have helped get life started.»
Scientists who are serious
about figuring out marijuana are breaking it down, looking
at the plant's active
molecules — cannabinoids — one by one.
New research
at Rockefeller University and Columbia University suggests these small
molecules may be able to relay valuable information
about damage to the heart: Scientists in Thomas Tuschl's Laboratory of RNA Molecular Biology have linked an increase in certain microRNAs circulating in the blood with injury to cardiac muscle.
«It's the first time a genome the size of a bacterium has chemically been synthesized that's
about 20 times longer than [any DNA
molecule] synthesized before,» adds Christopher Voigt, an assistant professor of bioengineering
at the University of California, San Francisco, who was not involved in the study.
When he and his colleagues
at Scripps and Brigham Young University ran a methane reaction with thallium — a main group metal — alkanes pushed the solvent
molecules aside 22 orders of magnitude faster than when the reaction was run with iridium, reducing the overall energy required by
about one - third, they report online today in Science.
Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein
about which little was known
at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic
molecules or a signaling protein partner.
A multi-institutional international study led by scientists
at The University of Texas MD Anderson Cancer Center has revealed new information
about how
molecules called long non-coding RNAs (lncRNA) interact with HIF - 1, a signaling pathway that is overexpressed in many cancers.
Killian said the new
molecules are only stable
at extraordinarily cold temperatures —
about a millionth of a degree above absolute zero.
Researchers
at Pacific Northwest National Laboratory and East China Normal University devised and tested a thin -
about as thin as the skin of a soap bubble - film composed of a special type of
molecules called peptoids that can repair itself, similar to the self - repair seen in cells of living organisms.
«It is amazing that we can make one genetic adjustment and positively impact on lifespan and intestinal health, understanding more
about the underlying
molecules at work here promises new strategies for anti-ageing therapies,» says Dr Jennifer Tullet from the University of Kent.
«Vibrations of
molecules — which provide chemical information
about what a material is — often occur
at a frequency that corresponds in energy to this bandgap that you can tune through,» McEuen said.