By joining information
about our genome with other clinical and diagnostic information, patterns can be identified and help to determine our individual risk of developing disease, detect illness earlier and determine the most effective interventions to improve our health.
Not exact matches
A former health care investment analyst
with a degree in biology from Yale University and current CEO of the company, Wojcicki is fascinated by the mysteries of the
genome and what it can reveal
about the human body.
[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks
about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing
genomes [8:55] Life - work integration [11:15] Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00] Thinking 10x bigger [28:00] Surrounding yourself
with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process
Regarding «Junk DNA,» yes, previous assumptions
about the role of non-coding DNA have been replaced
with an appreciation for other roles in regulation of coding regions, but this simply doesn't support the notion that our
genomes were intelligently designed.
With the advances in knowledge that are almost certain to be gained from the Human
Genome Initiative — or, if its critics should win the day and it lose support, from more piecemeal genetic - research — we will know more and - more
about genetic factors causally related to health and disease and to other important aspects of life, such as intelligence and emotional states.
Well, a review article in the current issue of The New England Journal of Medicine talks
about how knowledge of a patient's
genome is allowing doctors to pick the best drug for that patient, along
with dosage and duration of treatment.
The group also compared the cat
genome with those of other mammals — including a tiger, cow, dog and human — to understand more
about the genetics of cat biology.
Earlier surveys of Americans (here and here) have found a reluctance to support human
genome editing,
with many respondents expressing ethical and other concerns
about such intentional tinkering.
A decade ago biologists and nonbiologists alike gushed
with optimism
about the medical promise of the $ 3 - billion Human
Genome Project.
Arthur Caplan, a bioethicist at the University of Pennsylvania in Philadelphia who advises the US government on reproductive technologies, is sceptical
about the idea of making virus - resistant people, because anyone modified in this way would only be able to conceive children naturally
with a partner whose
genome had been altered in exactly the same way.
The work, funded by the US National Human
Genome Research Institute, aims to create human cell lines
with subtly different
genomes in order to test ideas
about which mutations cause disease and how.
Armed
with genome - sequencing technology that enables scientists to glean details
about where the infection comes from and to what extent it is related to antibiotic use on farms, policy makers will be better poised to tamp down the threat.
About 3.5 percent of our
genome consists of non-protein-coding DNA that we share
with mice and rats but whose function is not known.
About this Book: Modern Prometheus Editing the Human
Genome with CRISPR - CAS9 Jim Kozubek Cambridge University Press, 2016
Reis's group, the German Mental Retardation Network, has already sequenced the exomes — the 1 — 2 % of the
genome that contains instructions for building proteins — of
about 50 patients
with severe intellectual disability.
Afterward, a technician from the main hospital in the Faroes squirted
about 2 milligrams of blood into a special tube
with buffers to purify and stabilize his DNA, so that it could be sent to a laboratory to sequence the 3 billion letters that make up the code of his
genome.
In the end, Venter says, his team built, designed, and tested «multiple hundreds» of constructs before settling on Syn 3.0,
with a
genome about half the size of Syn 1.0's.
The sequencing of the oldest mammalian
genome from an ancient polar bear jawbone provides clues
about these animals» fraught relationship
with climate change
While Jarvis and
Genome 10K were deciding which avian
genomes to sequence,
with Jarvis making sure the list included vocal learners and species believed to be their close relatives, they learned
about another collaboration in the works led by Guojie Zhang of Chinese sequencing giant BGI and University of Copenhagen evolutionary biologist Tom Gilbert.
«Right now, the research group is analyzing the nuclear
genome the results of which could provide us
with information
about its relationship
with the Neanderthals and
about the existence of genomic variations associated
with the immune system that accounts for the evolutionary success of Homo sapiens over other human species
with whom it co-existed.
To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the
genome with large - scale data
about the output of those genes at specific times, in specific places, in response to specific environmental pressures.
Speakers include Penn State's Peter Hudson, who talks
about disease transmission; Oxford's Oliver Pybus, on how
genome analysis exonerated health care workers accused of infecting children
with HIV; and N.Y.U.'s Martin Blaser on our disappearing stomach flora.
While policy - level discussions
about the regulations of
genome - edited organisms are slowly taking place around the world, according to Dr. Ishii, his study will serve as a basis for the conversation
with regulatory agencies in the world as well as the Japanese Ministry of the Environment.
However, only
about 20 per cent of the heritability of type 2 diabetes has been explained by
genome studies of people
with the disease.
Only
about 100 of the tens of thousands of genes that make up the human
genome are marked
with these gender - specific stamps, subsequent studies showed.
In collaboration
with Prof. Ido Amit of Weizmann's Immunology Department, they analyzed the
genomes of 1,500 individual liver cells, establishing patterns of expression for
about 20,000 genes in each cell.
The gift accompanies a paper published online today in Nature from researchers at Broad and worldwide, which identifies more than 100 areas of the human
genome associated
with schizophrenia, based on samples from almost 37,000 people
with schizophrenia and
about 113,000 without the disease.
Lander argued that we know far too little
about the human
genome's role in cognition and other traits to try to mess
with it.
Even
with whole
genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein - coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous - Paleogene mass extinction event
about 66 million years ago.
The comparison
with other sequenced
genomes revealed that over the course of great ape evolution,
about 90 % of the
genome has been influenced by natural selection.
They show that
about 92 per cent of the population harbors bacteria
with a variant of the gene sequence, according to a survey of public
genome data from 250 adult humans.
The
genome shares
about 60 % of its genes
with the other invertebrates completely sequenced, such as the nematode and fruit fly, whereas
about 5 % match sequences found only — up to now, at least — in the human, mouse, and puffer fish
genomes.
Related sites Brief description of the tunicate
genome project,
with links to tunicate biology sites More information
about Ciona
Related sites NHGRI site
with general information
about the Human
Genome Project Wellcome Trust Sanger Institute site
about the Human
Genome Project Chart
The chimp
genome sequence, which consists of 2.8 billion pairs of DNA letters, will not only tell us much
about chimps but a comparison
with the human
genome will also teach us a great deal
about ourselves.
In contrast, the eastern wolf is mostly gray wolf,
with about 50 % to 75 % of its
genome assigned to that species.
The turkey
genome, published in September 2010, will provide Coulombe and other researchers
with a new level of detail
about the offending genetic mutation and the DNA sequences that regulate it.
To expand knowledge
about parasitic plants, the IU team chose to sequence the mitochondrial
genomes of Santalales, more commonly referred to as mistletoes, which are the largest order of parasitic plants in the world
with over 2,000 species.
Twins in the study whose
genomes showed a low risk for Alzheimer's, for example, did have
about a 12 percent (thus, much, much smaller) risk than that of the general population (which, to begin
with, has a relatively small risk of getting Alzheimer's during their lifetimes).
When the Max Planck scientists compared the bonobo
genome directly
with that of chimps and humans, however, they found that a small bit of our DNA,
about 1.6 %, is shared
with only the bonobo, but not chimpanzees.
Ever since researchers sequenced the chimp
genome in 2005, they have known that humans share
about 99 % of our DNA
with chimpanzees, making them our closest living relatives.
Similarly, the pufferfish,
with about 31,000 genes, probably has as many as a human, but they're housed in a
genome one - eighth the length of the human
genome.
It scans a very broad area of the
genome (508 genes and more than two million base pairs or letters of the
genome, i.e.. A, T, C, and G)
with high accuracy (each region of the
genome is sequenced or «read» 60,000 times), yielding
about 100 times more data than other sequencing approaches.
Dillman explained that his research team also learned more
about gene regulation and the evolution of
genomes in general as it compared the five sequences
with other nematodes.
But rather than simply debunking a myth
about the heirloom's diversity, Tanksley's deconstruction of the tomato
genome, along
with work by others, is showing how an unassuming berry from the Andes became one of the world's top crops.
ENCODE provided us
with information
about where along the full
genome DNA is read and how it is modified
with biochemical tags,» says Brad Gulko, a Ph.D. student in Computer Science at Cornell University and lead author on the new paper.
When the scientists sequenced the
genome of the new virus and compared it
with the original strain, they discovered
about five changes that allowed ferrets to pass the germ on.
I mean, I would say the whole last 30 years have been remarkable times because so many new techniques have come online: dating, CT studies, the synchrotron, allowing us to look [at] individual growth lines in Neandertal teeth,... the ability to date things
with much greater precision, and then DNA — and, you know, I was in Svante Pääbo's press conference in London in 1997 when [he] announced the first mitochondrial DNA and I went on record saying it was the equivalent in paleontology if landing something or landing on Mars and who could have imagined 10 years later we talk
about the whole
genome; it's incredible.
Over the past 20 years the public has been repeatedly told that these big genomic projects — starting
with the Human
Genome Project and going on through various other projects — were going to explain everything we needed to know
about the «book of life.»
The Streptococcus pneumoniae
Genome Diversity Project More information
about S. pneumoniae, on a site supported by vaccine manufacturer Wyeth - Lederle List of the more than 45 microbial
genomes so far completed,
with links to others still in progress