If researchers can use the mice to gather information
about specific tumor responses to specific drugs, then they can bank that information to be used in the general population.
Not exact matches
«When most people think
about cancer genetics, they think
about single key mutations that foster
tumor formation — very
specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.
A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by
about five months Findings from two phase III studies showing that children with Wilms
tumor who have a
specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen
For example, drugs that target a
specific BRAF gene mutation commonly found in melanoma shrink
tumors in
about half of patients with the mutation.
About half of melanoma patients harbor an identical
tumor -
specific mutation in the BRAF gene, which encodes a protein kinase that helps drive cell growth.
«This is what we have dreamed
about: drugs that can be targeted to a patient's
specific tumor, to the mechanism that caused the cancer,» says Alice Shaw, Martensen's oncologist and a chief investigator in the Xalkori clinical trial at Mass General.
Comparing proteins within the microvesicles with the originating
tumors showed that the vesicles also accurately reveal the protein content of the
tumors, providing still more information
about how
tumors might respond to
specific therapies, the researchers report.
We know little
about the
specific stimuli that make plasma cell
tumors develop but in humans, risk factors include exposure to petroleum products and radiation.