In essence, the signers were trying to get the President to change his mind
about stem cell lines used for research so that Congress does not have to create a legislative solution.
Not exact matches
About three - fourths of the
stem cell lines were found to be unsuitable for research, and many if not all the
lines were contaminated with mouse feeder
cells.
Another problem is that in its July 2009 Guidelines on Human
Stem Cell Research, NIH spelled out specific requirements
about embryo donation for newly derived
lines, says Pilar Ossorio, a legal scholar who studies research ethics at the University of Wisconsin Law School.
Intestinal
stem cells are particularly important because a new intestinal
lining is generated
about every 4 - 5 days.
«The beautiful thing,» Lanza says, «is that if you have an embryonic
stem cell line that is O negative, because it's immortal you could create an unlimited amount of universal blood that would match virtually everybody, so you wouldn't have to worry
about matching blood types.»
Studies in diabetic rodents suggest that diabetes may alter the intestine's mucosal
lining, which is maintained and regenerated by intestinal
stem cells; however, little is known
about how this occurs and whether it is relevant to humans.
The challenge, he says, will be figuring out how to force the transition from progenitors to
stem cells, which spontaneously occurred in
about one third of testicular
cell lines.
«While we expected to find some mutations in
stem cell lines, we were surprised to find that
about five percent of the
stem cell lines we analyzed had acquired mutations in a tumor - suppressing gene called p53,» said Merkle.
During the next five years, KOMP2 will transform the knockout mouse embryonic
stem (ES)
cells into adult mice for 2,500
lines of well - characterized knockout mice strains, and IMPC will create
about 2,500 additional knockout mouse strains.
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He added: «Truly naive human ES
cell lines would not only help answer fundamental questions
about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against which other types of
stem cells could be measured in terms of their effectiveness in
stem cell therapy and regenerative medicine.»
Such an immunological exemption could alleviate many concerns
about using
cells for therapy that don't exactly match the recipient's immune system - such as existing embryonic
stem cell lines that are not directly derived from the recipient.
The Coriell Institute provides information
about stem cells and holds a considerable collection of tissue samples,
cell lines and pluripotent
stem cells.
With
about 100
lines of code, a Morgridge Institute for Research team has unleashed a fast, simple and predictive text - mining tool that may turbo - charge big biomedical pursuits such as drug repurposing and
stem cell treatments.
Without these two technologies that you'll hear
about in a moment, there would be no such thing as human embryonic
stem cell research, and President Bush could have enjoyed his summer vacation in Crawford without having to agonize over the baptism of the infamous 64
stem cell lines.
Kucherlapati: Without thinking
about modifying the human genome
line, would this technology have the ability to affect the health of humans by modifying the
stem cells?