Sentences with phrase «accelerated aging mice»

Not exact matches

In the early»90s, Bartke wrote a grant application proposing to study the giant, growth - hormone - flooded mouse as an example of accelerated aging.

Because patients with TTD, XPCS, and CS (but not XP) and the corresponding mouse models share similar accelerated progeroid symptoms [12,13,15,23], we next addressed ageing - related parameters in compound heterozygous mice (Figure 3).

In SIRT6 knockout mice, which exhibit accelerated aging phenotype, haploinsufficiency of p65 subunit of NF - kB resulted in improved lifespan 33.

(8) Imputation of these results specifically to the animals» age - related, low - BubR1 - driven rise in p16Ink4a - expressing senescent cells was, however, limited: limited by the very nature of so - called «accelerated aging» models such as BubR1H / H, (9) and limited by the lifelong, global absence of p16Ink4a expression in the backcrossed mice.

Nevertheless, any direct evidence linking DNA damage to chronic inflammation stems from recent findings in progeroid (accelerated aging) syndromes and accompanying mouse models that carry inborn DNA repair defects.

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.

The scientists commented in the conclusion that «these results suggest that oleuropein accelerates skin wound healing in aged male Balb / c mice».

For example, results of a mouse study conducted by the National Institutes of Health (NIH) in collaboration with ChromaDex published in November 2014 indicated that NR was effective at restoring NAD + levels in mitochondria and rescuing phenotypes associated with a devastating accelerated aging disease known as Cockayne Syndrome (CS).