Sentences with phrase «accelerates cell senescence»

This accelerates cell senescence, which leads to increased pro-inflammatory and pro-oxidant signaling by the senescence associated secretory phenotype (SASP) response, and induction of mitochondrial dysfunction, thereby propagating DNA damage and senescence to bystander cells.

Not exact matches

Cardiovascular disease and renal disease for example are accelerated in patients with diabetes and AGEs have been shown to induce senescence in cell types related to these diseases, such as endothelial progenitor cells, vascular endothelial cells and renal cells.