Sentences with phrase «acceptable safety profile»

Although existing interventions have helped to reduce malaria deaths significantly over the past 15 years, a well - tolerated and effective vaccine with an acceptable safety profile could add an important complementary tool for malaria control efforts.

The drug had an acceptable safety profile.

A team led by principal investigator Donald M. O'Rourke, MD, an associate professor of Neurosurgery at Penn, and Marcela Maus, MD, PhD, showed that CART - EGFRvIII cells had an acceptable safety profile, crossed the blood - brain barrier, infiltrated the tumor, and prompted an immune response, resulting in reduction of the EGFRvIII tumor antigen in GBM cells.

The therapy was found to have an acceptable safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR trials.

Because intermittent fasting and CR have not been conclusively proven to have beneficial effects in humans with acceptable safety profiles (1), they were not considered to be controls for trials that were identified.