Especially, the role
of accessory proteins within the coordination of TCS response is only partly understood.
The genes that encode the botulinum toxin protein along
with accessory proteins that protect the botulinum toxin and ensure it functions, are organised as a gene cluster.
This search identified a previously undiscovered gene cluster encoding a new botulinum neurotoxin and
accessory proteins in the genome of a species of Enterococcus bacteria isolated from cow faeces.
Two
accessory proteins orchestrate the Cpx - TCS: The periplasmic protein CpxP inhibits the Cpx - TCS in unstressed cells and detects misfolded envelope proteins; the outer membrane lipoprotein NlpE activates the Cpx - TCS during biofilm formation.
Finally, to understand the coordination of signalling, we will study the plasticity of
accessory protein dependent and independent signals for the Cpx - reponse.
A key advantage of the system is that Cre acts independently of any
other accessory proteins or co-factors, thus allowing for broad applications in a variety of experiments.
Thus, some
ECCMC accessory proteins may play a role not only in regulating excitation - contraction coupling but also as modifiers of the ryanodinopathies phenotype.
What is the effect of the HIV - 2
accessory protein Vpx on HIV infectivity and the cell death pathway in lymphoid CD4 T cells?
Kennedy, J. Auclair, K. Kendrew, S. G. Park, C. Vederas, J. C. and Hutchinson, C. R. Modulation of polyketide synthase activity
by accessory proteins during lovastatin biosynthesis.
«Just the naked DNA, just the chromosome itself without
any accessory proteins, is all that is necessary to boot up this cell system.
Model depicting proposed functions of
the accessory proteins CpxP and NlpE for stimulus perception by the Cpx system Direct interaction between a CpxP dimer and CpxA keeps the sensor kinase in an «Off» mode.
Since then, Skordalakes and his colleagues have continued their structural studies on
the accessory proteins associated with telomerase that help regulate the enzyme's activities.