Sentences with phrase «accumulate as aggregates»

It has been shown that mouse IAPP is not amyloidogenic and does not accumulate as aggregates in the pancreas (Westermark et al., 1990; Janson et al., 1999; Ritzel and Butler, 2003).

A protein was engineered so that it accumulated as aggregates in the endoplasmic reticulum.

Not exact matches

IAPP aggregation starts as small, intracellular aggregates and later becomes accumulated as massive, extracellular deposits over time.

Lewy bodies (LB) and other intracellular α - synuclein (AS) aggregates accumulate in the aging nervous system, and a high burden of such aggregates are hallmark neuropathological signs of Parkinson's disease (PD), Lewy body dementia (LBD), multiple systems atrophy (MSA), and other synucleinopathies.

The RTM hypothesis is that the immune systems of people who reach the ages at which AS, beta - amyloid, and other pathological aggregates begin to accumulate would generate antibodies against their abnormal form, and that people who remain free of these specific diseases might be producing antibodies that are particularly effective at keeping these aggregates at bay.

[15] Significant recalcitrant (proteinase K - resistant) AS aggregate accumulated in the neuronal synapses of untreated PDGF - AS mice, as indicated by colocalization with synaptophysin staining; AFF 1 treatment significantly cleared this depot as well (Figure 3 (d)-RRBAS aggregate accumulated in the neuronal synapses of untreated PDGF - AS mice, as indicated by colocalization with synaptophysin staining; AFF 1 treatment significantly cleared this depot as well (Figure 3 (d)-RRBAS mice, as indicated by colocalization with synaptophysin staining; AFF 1 treatment significantly cleared this depot as well (Figure 3 (d)-RRBas indicated by colocalization with synaptophysin staining; AFF 1 treatment significantly cleared this depot as well (Figure 3 (d)-RRBas well (Figure 3 (d)-RRB-.