Sentences with phrase «accumulate in a tumor»

Once it is injected into the bloodstream, the FDG probe quickly accumulates in tumors, which tend to make heavy use of glucose.

A radiopharmaceutical made of such a compound will quickly accumulate in tumors.

«With that intervention, T cells were able to invade and accumulate in the tumor.»

They injected the bacterium into the tail veins of rats and demonstrated that B. longum is accumulated in the tumor.

Not exact matches

Chan's laboratory uses genomic analyses to identify neoantigens — novel peptides found only in tumors that arise from mutations accumulated by cancerous cells.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

Once injected, they accumulate in solid tumors.

These particles congregate at tumor sites, where MMPs cleave hundreds of peptides, which accumulate in the kidneys and are excreted in the urine.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

It is well established that melanoma cells can spread through the blood to accumulate and form new tumors (metastases) in other parts of the body away from the original tumor.

In recent years a body of evidence has accumulated to show that chronic inflammation can play an important role in the progression of some types of tumors from a premalignant state to full - blown diseasIn recent years a body of evidence has accumulated to show that chronic inflammation can play an important role in the progression of some types of tumors from a premalignant state to full - blown diseasin the progression of some types of tumors from a premalignant state to full - blown disease.

In some cases, patients» tumors develop resistance to Gleevec — either the Abl protein mutates so that the drug can no longer bind to it, or the protein accumulates in such quantities that the drug can't keep up, even at the highest dosIn some cases, patients» tumors develop resistance to Gleevec — either the Abl protein mutates so that the drug can no longer bind to it, or the protein accumulates in such quantities that the drug can't keep up, even at the highest dosin such quantities that the drug can't keep up, even at the highest dose.

The researchers found that OTL38 accumulated in FRα - positive tumors and metastases, and enabled the surgeons to remove an additional 29 percent of malignant lesions (confirmed by pathological examination of the resected tumors) that could not be identified with naked eyes and / or palpation.

Researchers from Charité — Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam - Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal.

Treatment of brain tumors is particularly challenging because regulatory T - cells accumulate in brain tumors and suppress an immune attack.

The findings are significant, because the nanoparticles not only remained in circulation, but also accumulated in mouse tumors, as well as in the lungs of healthy mice, suggesting that the approach also may enhance treatment for lung diseases.

He says that the new nanoparticles accumulate preferentially in tumors, which could drastically reduce the side effects of current cancer treatments that usually kill healthy cells along with the targeted cancer cells.

The researchers discovered a single letter variant located in TP53, a gene known to play a central role in tumor biology and for accumulating so called somatic mutations, during the development of cancer in patients.

Aerosol administration was performed as follows, the residual cup was filled with 8mls of the cisplatin agent and the nebulisation time was 10 minutes (almost 1 ml / minute) as observed from our previous studies.14 The aerosol was delivered to the mice (one by one) within a nose only cage that has been previously presented.34 In the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulateIn the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulatein different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulated.

Results published by the Altieri laboratory demonstrated that these molecules accumulate in mitochondria of tumor cells, where they physically interact with components of the organelle permeability transition as well as with a number of regulators of bioenergetics, including the control of protein production, lipid metabolism and ATP generation.

Though this exploitation of biochemical and cellular pathways, the Gelipo - TRAIL - Dox combo accumulated more than the controls in the affected tumor tissue and had a greater cytotoxicity.

Because the majority of angiogenesis regulatory factors appear to be sequestered in platelets, which possess the ability to selectively accumulate these factors in patients with cancer, they have the potential to detect tumor growth before it is clinically apparent.

Dr. Matsuzaki has accumulated extensive expertise in T - cell biology and mechanisms of immune suppression in periphery and tumor microenvironments in patients with ovarian cancer.

To date, they have shown that BiTEs are: (1) highly - specific molecules that greatly reduce the risk of toxicity; (2) have the ability to penetrate the blood - brain barrier and accumulate in intracerebral tumors; and (3) may potentially overcome multiple mechanisms of immunosuppression present in patients with glioblastoma.

Accumulate in the liver and lymph nodes and may promote tumors.

MacAllister explains «the higher incidence of nasal tumors for long - nosed breeds probably occurs because these types of breeds have a greater surface area in their noses to be exposed to the carcinogens and for the carcinogens to accumulate.