Our mouse model data are not in conflict with the epidemiological observation that a first pregnancy before age 22 greatly reduces breast cancer risk (MacMahon et al., 1970), because at this young age, the chance of having already
accumulated precancerous cells is small.
Not exact matches
However, when old cells return to a stem cell - like status, they can carry with them all of the mutations that have
accumulated to date, predisposing some of those cells to developing into
precancerous lesions.
One theory widely accepted by cancer researchers is that tiny
precancerous lesions
accumulate throughout the body because of random mutations or exposure to small amounts of carcinogens.