Not exact matches
Each genetic
mutation produces only a very
small change in the biological features of the organism, but such
small changes
accumulate over immense periods of time and lead to the evolution of new species from old.
Excoffier and his colleagues developed theoretical models predicting that if modern humans migrated as
small bands, then the populations that broke off from their original African family should progressively
accumulate slightly harmful
mutations — a
mutation load.
Genetic diversity indicates the past abundance of a species because large populations tend to
accumulate diversity through random DNA
mutations and breeding, while
small populations lose it through inbreeding.
One theory widely accepted by cancer researchers is that tiny precancerous lesions
accumulate throughout the body because of random
mutations or exposure to
small amounts of carcinogens.
And judging from the
small number of
mutations it had
accumulated, it came from there only about a thousand years ago.
Over the very period that the brain shrank, our DNA
accumulated numerous adaptive
mutations related to brain development and neurotransmitter systems — an indication that even as the organ got
smaller, its inner workings changed.
The fact that animals can reach centuries lifespans, not develop cancer and most likely
accumulate some
small nDNA deleterious
mutation load over time could mean that nDNA
mutation are not as deleterious as say mtDNA deletions
mutation.