But while substantial data (including AFFiRiS» [15] and Prothena's [20,22] preclinical work) give good reason to think that early clearance of AS neuropathology will decelerate the rate of SN DA neuronal loss, astrocytosis, and possibly
accumulation of senescent glial cells in PD, there is no reason to think that doing so will prevent these phenomena entirely, if for no
other reason
than because many
other factors also contribute to their occurrence.
Other factors include absence of pathologic fracture, less
than 360 degree involvement of soft tissues and firm soft tissue mass versus an edematous (An excessive
accumulation of serous fluid in tissue spaces or a body cavity) lesion.