Sentences with word «achlorhydria»

Similarly, a study from Denmark by Christiansen showed that the incidence of achlorhydria in patients increased rapidly from 1.8 % in the fifth decade to 18.5 % in the eighth decade.

Several conditions associated with achlorhydria lead to increased mortality and morbidity.

Rantala A, Ovaska J. Association between medically induced achlorhydria of the stomach and a severe postoperative infection?

Prevalence of achlorhydria in a normal population and its relation to serum gastrin.

In these patients, achlorhydria leads to pronounced hypergastrinemia (> 1000 pg / mL) with subsequent hyperplasia of gastric ECL cells.

Atrophic gastritis (and associated achlorhydria) has been considered to be a potential precursor to gastric carcinoma.

This developed most of the changes seen in human patients, including not just achlorhydria (a lack of or total absence of gastric secretions in the stomach), but also iron - deficiency anemia and other pathological changes that replicate the human clinical traits involved, through the presence of which the researchers were able to confirm the mutation as the primary one responsible for the development of gastric NETs.

«Additionally, the genetically - engineered mouse model will allow us to test potential treatments aimed at correcting achlorhydria, not just for gastric NETS, but also for other diseases of the gastrointestinal system such as Barrett's esophagus (chronic inflammation of the lower part of the esophagus), or hiatus hernia,» says Dr Calvete.

Some people, particularly our older population, may actually have a condition known as achlorhydria, in which a person produces very little stomach acid.

Development of sustained achlorhydria in a patient with the Zollinger - Ellison syndrome treated with omeprazole [published erratum appears in Gastroenterology 1992 Mar; 102 (3): 1096].

For practical purposes, gastric pH and endoscopy should be done in someone with suspected achlorhydria.

These findings suggest an association between achlorhydria related to PPI use and hip fracture.

Therapeutic achlorhydria and risk of gastric cancer.

Gastric knockout mouse models with inactivated parietal cells subsequently develop achlorhydria.

More serious reduction in stomach acid — or the production of none, called achlorhydria — is seen in serious illness such as intestinal cancer.

In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology.

Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria.

According to a report by Segal et al of 1590 patients, the incidence of achlorhydria was 19 % in the fifth decade of life and 69 % in the eighth decade of life.

Two major gastric surgeries also lead to achlorhydria.

A clear association between increased age and achlorhydria has been established.

Third, achlorhydria has been defined as a ratio of serum pepsinogen I / pepsinogen II of less than 2.9.

Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H + / K + - ATPase activity can induce achlorhydria.

Irrespective of the cause, achlorhydria can result as known complications of bacterial overgrowth and intestinal metaplasia and symptoms are often consistent with those diseases:

Is achlorhydria a cause of iron deficiency anemia?.

In a gastrin knockout model, achlorhydria is present because of the inactivation of enterochromaffinlike (ECL) cells and parietal cells.

The «Heidelberg test» is an alternative way to measure stomach acid and diagnose hypochlorhydria / achlorhydria.

Several medical conditions and specific gastric surgery can lead to achlorhydria; all of which are described in this article.

Parietal cell antibodies are found in 20 % of patients with type 1 diabetes, denoting autoimmune gastritis, achlorhydria, and pernicious anemia.

First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women.

Primary gastric lymphoma presenting with vitamin B12 deficiency and achlorhydria.

Andersen J, Strom M. Pentagastrin given during upper gastrointestinal endoscopy: a simple screening method for hypo - and achlorhydria.

However, treatment of these disorders has no known effect in the treatment of achlorhydria.

Little is known on the prognosis of achlorhydria, although there have been reports of an increased risk of gastric cancer.

The incidence of achlorhydria and hypochlorhydria in healthy subjects and patients with gastrointestinal diseases.

The absence of the H + / K + - ATPase is chronically associated with achlorhydria and mucosal hyperplasia but with no histological evidence for neoplasia.

Second, achlorhydria has been defined by a maximal acid output of less than 6.9 m / mole / h in men and less than 5.0 m / mole / h in women.

[15] The increased rate of achlorhydria was also associated with a rise in the frequency of gastric cancer.

The relationship between parietal cell function and achlorhydria is illustrated using genetic knockout mice models, as follows:

Studies from Europe have reported the prevalence of achlorhydria to range from 1 - 4.7 % in healthy subjects.

Specifically, achlorhydria has been associated with the following major sequelae: gastric cancer, hip fracture, and bacterial overgrowth.

A technique for screening of achlorhydria and hypochlorhydria during upper gastrointestinal endoscopy.

This cytokine release can affect ECL cells by impairing their secretory function and lead to achlorhydria and subsequently gastric cancer via ECL hyperplasia by increased gastrin stimulation.

Bone mineral density (BMD) was monitored by lumbar dual photo absorptiometry, and other factors such as hypothyroidism and achlorhydria were adjusted as required.

Of the many factors that contribute to compromised digestive capacity, insufficient stomach acid (hypochlorhydria, achlorhydria) and diminished pancreatic enzyme production are two of the most common.

Low gastric acid secretion (achlorhydria or hypochlorhydria) probably do not significantly affect protein digestion [132 - p. 33; 133].

Both achlorhydria and pancreatic insufficiency are associated not only with impaired digestion but with complications such as malnutrition and small intestinal bacterial overgrowth (SIBO).

Calcium citrate is the preferred calcium formulation for individuals who lack stomach acids (achlorhydria) or those treated with drugs that limit stomach acid production (H2 blockers and proton - pump inhibitors)(reviewed in 125).