«Nutrient deprivation kills kidney cancer cells: Cutting off amino
acid triggers cell death in cancers.»
Not exact matches
A malfunction of fatty
acid regulation can, however, lead to
cell death and — depending on the type of
cell —
trigger diseases such as diabetes.»
The fatty
acid also increased the effectiveness of Herceptin, a drug made from antibodies that latch onto HER2 proteins and
trigger the
death of cancer
cells.
In the current issue of Nature Medicine, John Pezzuto of the University of Illinois at Chicago and his colleagues report that a compound called betulinic
acid triggers apoptosis or programmed
cell death, in cultured melanoma
cells.
By depriving the cancer
cells of the amino
acid cystine, the researchers were able to
trigger a form of
cell death called necrosis in mouse models of the disease.
Blocking the proteasome prevents this regulated recycling of amino
acids and
triggers controlled
cell death, particularly in fast - dividing
cells typical of cancer.