We assume that phages
acquire resistance genes from already resistant bacteria and then transfer those genes to other bacteria,» says Hilbert.
Led by Newcastle University, UK, the study also showed that the repeated use of animal manure and antibiotic substitutes can increase the capacity of soil bacteria to mobilise, or ready themselves, and
acquire resistance genes to new antibiotics.
Conclusions: MinION sequencing comprehensively identified pathogens and
acquired resistance genes from urine in a timeframe similar to PCR (4 h from sample to result).
Results: MinION correctly identified pathogens without culture and, among 55
acquired resistance genes detected in the cultivated bacteria by Illumina sequencing, 51 were found by MinION sequencing directly from the urines; with three of the four failures in an early run with low genome coverage.
Not exact matches
The bacteria behind gonorrhoea readily
acquire genes for resisting drugs and so from 2012, UK patients were given two antibiotics at once — azithromycin pills plus a ceftriaxone injection — so if bacteria
acquired resistance to one, they would be killed by the other.
The desire of the host to
acquire antibiotic
resistance genes from its guest could have driven this chain of events, he says.
The researchers found that S. aureus
acquired the
gene that confers methicillin
resistance — mecA — as early as the mid-1940s — fourteen years before the first use of methicillin.
Five decades on from the appearance of the first MRSA, multiple MRSA lineages have emerged which have
acquired different variants of the
resistance gene.»
The
gene for methicillin
resistance, for example, had been
acquired by five separate strains in five different places.
The prevailing notion was that bacteria
acquire and maintain
resistance genes at a cost.
«The next step would be finding how they are
acquiring the resistant bacteria and what
genes are responsible for the
resistance patterns we found.»
When bacteria
acquire antibiotic -
resistance genes they become better at surviving in the body, challenging the dogma that
resistance comes with a cost
A team of French investigators now shows that bacteria that
acquire plasmids containing
resistance genes rarely lose them.
Bacteria can
acquire resistance by getting a copy of a
gene encoding an altered protein or an enzyme like beta lactamase from other bacteria, even from those of a different species.
Systemic
acquired resistance is induced by R
gene - mediated responses independent of cell death
We hypothesized that antimicrobial
resistance can be reversed by targeting chromosomal non-essential
genes that are not responsible for
acquired resistance but essential for resistant bacteria under therapeutic concentrations of antimicrobials.
Short - read, high - throughput sequencing technology can not identify the chromosomal position of repetitive insertion sequences that typically flank horizontally
acquired genes such as bacterial virulence
genes and antibiotic
resistance genes.
In addition, we found evidence that some strains have
acquired antimicrobial
resistance genes independently, presumably in response to antimicrobial treatment.
Our results indicate that
S. argenteus has spread at a relatively rapid pace over the past 2 decades across northeastern Thailand and
acquired multiple exotoxin and antibiotic
resistance genes that have been linked previously with livestock - associated
S. aureus Our findings highlight the clinical importance and potential pathogenicity of
S. argenteus as a recently emerging pathogen.
36) Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Genomic analyses identify
gene candidates for
acquired irinotecan
resistance in melanoma cells.