Sentences with phrase «across genes coding»

Then, 15 years ago, Shatz stumbled across genes coding for MHCI in fetal cat brains.

Not exact matches

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

Because genes and the proteins they code for are often highly conserved across species, the researchers suspect their discoveries — boosted by preliminary studies in mice — could lead to new treatments for people whose insomnia or off - hours work schedules keep them awake long after their heads hit the pillow.

The gene that codes for this clotting protein has a very similar sequence across many plant species, and the researchers showed that the microRNA from dodder targets regions of the gene sequence that are the most highly conserved across plants.

From these efforts, we identified a high - quality orthologous gene set across avian species, consisting of exons from 8251 syntenic protein - coding genes (~ 40 % of the proteome), introns from 2516 of these genes, and a nonoverlapping set of 3769 ultraconserved elements (UCEs) with ~ 1000 bp of flanking sequences.

For ~ 13,000 (low - coverage genomes) to ~ 18,000 (high - coverage genomes) annotated genes across avian species (44), phylomeDB inferred orthologs for 94.58 % of them and these agreed with the synteny - based orthology of the 8251 protein - coding genes of the TENT by 93 %.

The scientists sampled the genetic code of 400 trees from 31 locations across northern North America and combined the genetic variations with computer modeling techniques to map how important genes differ within balsam poplar and to locate where trees may have the best chance of survival in a rapidly warming world.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

They discovered that earwax type was determined by a change in just one DNA nucleotide in a gene called ABCC11, which was previously found to code for a protein involved in transporting molecules across cell membranes.

Professor Mathias Uhlen, Director of the Human Protein Atlas consortium and leader of the Pathology Atlas effort says: «This study differs from earlier cancer investigations, since it is not focused on the mutations in cancers, but the downstream effects of such mutations across all protein - coding genes.

Over 4 million coding mutations are described in v78 (September 2016), combining genome - wide sequencing results from 28 366 tumours with complete manual curation of 23 489 individual publications focused on 186 key genes and 286 key fusion pairs across all cancers.