Sentences with phrase «act on cells»

Caffeine is thought to act on the cells in the body by blocking adenosine (an amino acid) receptors.

9/26/2007 Enzyme's Second Messenger Contributes to Cell Overgrowth Scientists at the University of California, San Diego (UCSD) School of Medicine have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth.

«We have discovered some of Francisella's toxins, but still to be determined is how they act on the cells the bacteria infect.

They did so by including factors like the mechanical forces acting on the cells and the tumor's cellular heterogeneity.

Photoperiodic control of seasonal growth is mediated by ABA acting on cell - cell communication

AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.

Peg 3 enhances cell reprogramming by acting on cell metabolism.

Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates.

One type of GAG is dermatan sulfate, which, according to an article in Glycobiology, acts on cells in many different ways, including helping them regenerate and repair wounds.

Those constituents are being acted upon by the same gravitational «force» acting on the cell, and the work they do is going to cancel any change in overall energy due to gravitation other than that due to the tidal forces.

But, of greater import, there are forces acting on the cell due to neighboring constituents of the Sun, and the delta - kinetic energy has to include the contributions due to work done by them.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Looking people in the eye, listening to what they have to say and making an intelligent response that lets them know we really heard what they were saying, not acting like we're in a hurry to move on but have time to listen, letting them know they are more important than our stupid cell phones, encouraging them and letting them know we think they can succeed — all of those things are extremely important in building relationships, including relationships with homeless people.

This is the group of genes which act as the immune system markers on cells, protecting them from being attacked by the system's anti-bodies.

As members of society, the way that we act has the ability to impact others in big ways (global warming, racism) and in small ways (person talking on cell phone during a movie, smoker blowing smoke in your face as they pass you on the sidewalk).

That is because such a storm acts like a train, with individual storm cells rapidly reforming behind each other in a line, following a narrow path as if on rails.

The BHA contributes to debate on a wide range of ethical issues from stem cell research to sex education, and acts as a unique watchdog and lobbying organisation.

Epigenetic tags help tell genes — stretches of DNA that act as biological instruction manuals — when to switch «on» and «off,» ultimately determining cell type and function.

Those bubbles might act much as cell membranes do on Earth, sheltering genetic material and concentrating biochemical reactions needed for life.

The male sex hormone acts on a group of immune cells that are part of the first line of the body's defense against invaders.

Geron was bigger and better funded than ACT, and it was the first company to be approved by the US Food and Drug Administration (FDA) to test a therapy in humans based on embryonic stem (ES) cells.

Skop published her work in the 2 July 2004 issue of Science, and her image of Chinese hamster cells caught in the act of division landed on the cover.

«Understanding the balancing act in what makes up our bodies» lipids — between availability based on what we're eating and genetic guidance — is very important to cell biologists,» Farber explained.

PD - L1 sits on the surface of cells and acts as a kind of stop sign, telling T cells not to attack.

Benzodiazepines act on GABA receptors, making them stay open longer and allowing more negative ions into the cell that can inhibit communication between the cells.

Combing the genetic data from a transmission study in ferrets, a team led by Thomas Friedrich, a professor of pathobiological sciences at the University of Wisconsin - Madison School of Veterinary Medicine, found that during transmission, when one animal is infected by another through sneezing or coughing, the process of natural selection acts strongly on hemagglutinin, the structure the virus uses to attach to and infect host cells.

First, the trial tested GM - CSFs which act on more than one blood cell lineage and are not commonly used nowadays.

Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also controls aggressive behavior by acting in that cell.

The next step is to bind the modified toxin to receptors that will ensure it acts only on cells where it is needed.

Fast - acting neurotransmitters, e.g., glutamate (excitatory) and γ - aminobutyric acid (GABA)(inhibitory), achieve effects on their target cells within one millisecond by virtue of opening ligand - operated ion channels.

ACT's actions — and the highly politicized nature of stem - cell research — scared off investors, leaving the company teetering on the verge of bankruptcy for most of the past decade.

«In addition, there are plans for further molecular biological studies with the objective of understanding exactly how the 5 - LO inhibitors act on the leukaemic cells.»

Not only were all the toxins acting in the same way on cells, but they did so even when small amounts, similar to amounts found in the environment, were used.

«Thrombopoietin signals actually acted on stem cells and progenitor cells, several generations back.»

«What we think happens is that the bacteria activate immune cells, which release chemicals called cytokines that then act on receptors on the sensory nerves to increase their activity,» he says.

The gene encodes a protein called PD - 1 that normally acts as a check on the cell's capacity to launch an immune response, to prevent it from attacking healthy cells.

Unlike many drugs, minocycline can cross from the bloodstream into the brain so that it can act on the astroglial cells.

«We want to start looking system by system to see how widely acting this process is on different types of cells,» he says.

The insulin these cells produced acted on blood sugar levels in the same way as insulin from the pancreas.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

Endocannabinoids act on a group of cell - surface molecules called cannabinoid receptors that help to regulate appetite, mood and memory.

GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.

Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream.

A team led by Charles Zuker of the University of California, San Diego, focused instead on fruit flies, acting on a hunch that the flies» touch - sensitive bristles might contain channels similar to those in sound - sensitive hair cells.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

They also have varying effects if they act on different receptors — proteins in cell membranes that bind neurotransmitters and control cell responses.

Once Herceptin binds to HER2, however, DM1 is released and acts on cancer cells in the vicinity.

This RNA - based nanoparticle compound kills the cells by acting on the formation of vesicles.

The findings, published online this week by the Proceedings of the National Academy of Sciences, provide the strongest evidence to date in support of the notion that sex chromosomes acting on single cells play a role in differences between male and female brains.

A balancing act between forces forms similar structures inside cells and dense stellar corpses, suggesting links between astrophysics and life on Earth