Sentences with phrase «act on chromosome»

First, they determined how repair proteins failed to recognize and act on chromosome breaks during cell division.

Not exact matches

Researchers think it acts on another gene called lymphocyte activation gene - III, located at the other end of the same chromosome.

By altering the genetic variant on only one chromosome, the other chromosome remains unchanged and acts as an internal control.

Linkage studies use genetic markers, which act like signposts, pointing researchers to the general area on the chromosome where genes associated with certain traits likely reside.

The findings, published online this week by the Proceedings of the National Academy of Sciences, provide the strongest evidence to date in support of the notion that sex chromosomes acting on single cells play a role in differences between male and female brains.

They identified previously unknown recurrent loss - of - function mutations that target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible for genes to be expressed.

The chromosomes then head on to the poles» main sector, the centrosomes (organelles that act somewhat like roundabouts), and continue on through the main roads until they reach the spindle equator's parking zone.

An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres.

We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs.

Visualized in this manner, any patterns off of the diagonal (where a CNA influences a gene on the same chromosome) indicate a trans - acting event.

This observation led the team to propose that BRCA1 has an additional role in assisting neurons in orienting: the gene acts on the centromere of DNA — essentially an anchor for the chromosome arms essential in cell replication — to tell the new cell in which direction to grow, providing guidance in developing the brain's organized layers.

This is why two brothers in the same family can look and act totally different from one another even though they come from the same parents — it all depends on which genes (chromosomes) were randomly chosen when producing the sex cells of the mother and father.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

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