Previous molecules created to
act on human cells were shown to cause harmful side effects.
Not exact matches
Geron was bigger and better funded than
ACT, and it was the first company to be approved by the US Food and Drug Administration (FDA) to test a therapy in
humans based
on embryonic stem (ES)
cells.
«If you're looking for very specific molecular targets or pathways in the brain, and how drugs might
act on them, the difference between
human cells and mouse
cells is significant.»
Leptin
acts on human marrow stromal
cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes
Lipton went
on to state, «It will be important to see if HIV / AIDS
acts similarly
on stem
cells for other organs in the
human body, as this may impact
on the disease process as a whole.»
Recently, his lab used induced pluripotent stem (iPS)
cells — adult
cells made to
act like embryonic stem
cells — made from skin
cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects
on the development, survival, and degeneration of
human neurons.
The co-incidence of these 2 pathologies occurs also in
humans suggesting a common pathological mechanism moving across the gut - joint axis, with TNF signals
acting on specific
cell types directing pathogenesis at two different locations.
Targeting intracellular
human thymidylate synthase in live
cells, their pilot screen identified all drugs within the library known to
act on this enzyme.
Furthermore, saturated fat has been shown to have numerous positive effects
on health, such as improving liver health by encouraging the liver
cells to get rid of their fat
cells, improving the immune system's response by helping white blood
cells to recognize and destroy invaders more effectively, enabling the absorption of fat - soluble vitamins by
acting as their carriers, as well as improving hormonal activity by providing the building blocks for a variety of hormones that are essential to
human health.