Sentences with phrase «activate cell death»

Researchers, however, can now screen drugs to find compounds that might activate cell death in senescent cells, he says, or that might turn the immune system against senescent cells.

However, they may also activate cell death under certain conditions and assist in the removal of damaged cells from the body.

Excessive or uncontrolled inflammation can actually make injuries worse and contribute to disease in a couple of different ways — by activating cell death processes, clogging and rupturing blood vessels and producing toxic molecules like free radicals.

In a very interesting paper published in Molecular Cell (PMC4530630) they showed that SBI - 0206965 inhibits autophagy and activates cell death in tumor cells resistant to mTOR inhibitors.

Inducible defenses are also important and involve gene activated cell death and a subsequent «walling off» of living cells / tissues via induced biochemical processes, to slow the beetles» and fungus» physical progress in the tree.

Not exact matches

Once activated, the mechanism for programmed cell death shrinks the cell's nucleus, decreases the cell's fluid, or cytoplasm, and snips up the cell's DNA.

The c - MYC pathway appeared to some researchers to be an unlikely therapeutic target for beta cell regeneration because past studies had found it to cause beta cell death when activated in high doses.

In the study, published in Cell Reports, the University of Kentucky's Vivek Rangnekar and his colleagues activated wild type p53 in normal cells to trigger cell death in the p53 - deficient cancer ceCell Reports, the University of Kentucky's Vivek Rangnekar and his colleagues activated wild type p53 in normal cells to trigger cell death in the p53 - deficient cancer cecell death in the p53 - deficient cancer cells.

Other plasma - activated solutions have previously been shown to induce reactive oxygen species within cells, but these were not detected in plasma - activated Lactec (PAL)- treated cells, suggesting an alternative mechanism triggered cell death.

«The virus evokes a response in the infected cell that activates a pre-programmed cell death pathway,» said Stanley Lemon, M.D., one of the study's authors and a professor of medicine at UNC's School of Medicine and UNC's Institute for Global Health & Infectious Diseases.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

Gradual increase of p53 levels activates apoptosis promoting protein Bak on the surface of the mitochondria making these cells vulnerable to death.

While FOX01 does indeed promote cell death when it is highly activated, it does the opposite when moderately activated.

«Digoxin could be the key molecule that activates glioblastoma cell death during Zika infection,» Catharino said.

CNIO researchers have now discovered how the MCRS1 protein — a protein associated with gene regulation and cell death processes — is capable of activating mTOR, and thus, stimulate cell proliferation.

By taking out these survivor genes, the assassin molecule activates multiple death cell pathways in parallel.

«Onions activate pathways that encourage cancer cells to undergo cell death.

When researchers used a drug to block the action of the female sex hormone in female mice carrying the Nf1 mutation, they saw a drop in the number of activated microglia and a decrease in retinal damage and nerve cell death.

Then, when the researchers gave the mice a drug, the death pathway would be activated in all senescent cells.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated.

In mature nerve cells, the Burnham team had previously shown that HIV / gp120 activates the p38 MAPK pathway to contribute to cell death.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival.

Once inside, the virus's DNA acts as a danger signal that activates a protein called caspase 1, which can initiate cell death in several ways, including opening pores that disturb the cell's ion balance and releasing inflammatory signals that recruit other immune cells.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

Activation of ERK1 / 2 triggers G2 checkpoint which is considered protective from radiation - induced cell death [8, 9], while activated AKT is known to promote DNA repair and inhibition of apoptosis induction [10].

In a curious twist resembling cellular alchemy, when blood T cells are cultured with lymphoid tissue from the tonsils or spleen, the blood T cells begin acting like lymphoid tissue T cells, becoming more activated and more susceptible to abortive infection and death by pyroptosis.

Programmed cell death in plants: a pathogen - triggered response activated coordinately with multiple defense functions

By identifying, activating and inhibiting critical signaling nodes in cells, the scientists seek to better understand how these drive responses such as cell death and differentiation.

The halogens bromide, chloride, and fluoride compete with iodine for the receptor binding sites in the thyroid, but instead of activating the receptors they build up in thyroid tissue and cause thyroid cell death and inflammation.

According to researchers at UCLA's Jonsson Comprehensive Cancer Center, this activates a metabolic communication and amplification loop that ultimately leads to cancer cell death.

Our friendly flora's digestion of fiber also yields another short - chain fatty acid called butyrate, which may fight against cancer by slowing the growth of colon cancer cells and activating programmed cancer cell death — as well as preventing cancer in the first place.

Estrogen does this by activating a gene known as Bcl - 2 that slows the process of cell death, known as apoptosis.

JNK is a stress - activated protein kinase, or a SAPK, that plays a roll in everything from gene expression, to cell death, to energy production.

The drug within the tumor is activated by a specific wavelength of light to generate intracellular oxygen and lead to death of cells and / or loss of blood supply.

The virus activates growth - promoting genes in the DNA (oncogenes), at the same time it inactivates suppressor genes that would normally limit cell proliferation and alters the genes that regulate normal, programmed cell death.

It was already known that TAK1 activates two proteins that play a role in immunity, inflammation, programmed cell death and cancer.