Sentences with phrase «activate cell systems»

When dietary PUFA are not available, the body produces a small amount of unsaturated fatty acid (Mead acids), but these do not activate cell systems in the same way that plant - derived PUFAs do, and they are the precursors for an entirely different group of prostaglandins.»

Not exact matches

To fight this, Empliciti works to activate the body's immune system to fend off the cancerous cells.

The company leverages its unique insights in cancer biology and the immune system to discover and develop novel oral small molecules that activate immune responses to eliminate cancer cells.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

This gives just enough time for light signals from the baseball to hit the batter's eye, work through the circuitry of the retina, activate successions of cells along the loopy superhighways of the visual system at the back of the head, cross vast territories to the motor areas, and modify the contraction of the muscles swinging the bat.

Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.

SNAs have unique properties that allow them to reach cells safely without causing toxicity or activating the immune system.

An adenylate cyclase that is activated specifically by very low concentrations of octopamine has been identified both in homogenates and in intact cells of the thoracic ganglia of an insect nervous system.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

Mast cells, also known as «allergy cells,» are cells of the immune system which become activated by environmental allergens.

By studying infected cells grown in a laboratory, the team found that a large number of CMV's genes help it hide from the immune system by allowing it to destroy many of the proteins produced by the body during virus infection and preventing them from activating immune cells to destroy the virus.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

Two key attributes are that the system is genetically encoded and can activate cells remotely and quickly,» says Jeffrey Friedman, Marilyn M. Simpson Professor head of the Laboratory of Molecular Genetics at Rockefeller.

In each case, the mRNA encodes viral proteins that infected cells would normally present to activate the immune system and beat back an infection.

In effect, «if you activate the cannabinoid system» of these cells, Harkany says, «it will send a message to the cell that «I don't want to grow there, I want to grow somewhere else»» and connect to another cell.

This suggested to Siddle that in rare cases, the devils» immune systems were recognizing the tumor cells enough to release interferon - gamma and activate their MHC expression.

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

However, the Moffitt scientists suggest that it may be possible to target the TGF - β - miR183 - DAP12 pathway in patients with lung cancer to activate the immune system and kill cancer cells.

The reaction begins when an antibody activates a component of the immune system known as a mast cell, which then blasts out a barrage of chemicals.

University of Alabama at Birmingham researchers have now shown that activated T - cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

«The brain along with the reproductive system and every other cell in your body is exquisitely sensitive to exceedingly small changes in estrogen and other sex hormones, and the fact that the environment is full of chemicals that can activate estrogen receptors means this phenomenally sensitive system is being perturbed constantly by environmental factors.»

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

L2 plays an important role in cells by activating mRNA decay, a system cells use to turn off gene expression when the proteins encoded by the mRNAs are no longer needed.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

- GalCer ligands serve as tiny dock masters in our immune system, helping antigen - presenting cells attract and bind with iNKT cells so they can be activated to kill cancerous cells or fight off pathogens and other foreign invaders.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

Once activated, the researchers argue, these cells can breach the blood - brain barrier that normally keeps immune cells away from the nervous system.

Dr. Gabriel Ferguson, a postdoctoral fellow in the lab of Dr. Martinez - Agosto and first author of the study, built upon the lab's previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury.

«These cells can rapidly change they status, from quiescent to activated and vice versa, for the immune system to work well.

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez - Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection.

Until now, most researchers have focused on one of two strategies: attacking tumors with antibodies, which activate the innate immune system, or stimulating T cells, which form the backbone of the adaptive immune system.

Instead, the vaccines use killed autologous tumor cells from the patient to activate the immune system.

«How stem cells can be activated to help immune system respond to infection.»

TIM - 3 is known to play a critical role in regulating the immune system, suggesting that it may be possible to target TIM - 3 on dendritic cells in order to activate T cells.

Normally, when the body detects an outside invader such as a virus, a signalling system known as the PKA pathway responds by turning on 99 genes that then activate T - cells to destroy the invader.

For example, Hearl says, «If you can weaken cancer cells through a small molecule treatment and then come after it with an activated immune system, you end up with a very effective one - two punch.»

New drugs that activate the immune system to target cancer cells have improved the lives of many patients with cancer.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

The drug forms a complex with cyclophilin A and a third protein, calcineurin, which is needed to activate the T cells of the immune system.

Looking forward, Gimi's work will focus on using these microencapsulated cells to stimulate the immune system to act against tumors, as well as activating drug synthesis.

«Nuclear DNA gets cut, activates immune system to attack cancer cells.»

Investigations of how short chains of nucleic acids replicate themselves in vitro have even provided clues to primitive genetic codes for translating nucleic acid information into protein information, systems that could have preceded the elaborate machinery of ribosomes and activating enzymes with which cells now manufacture protein.

During inflammatory responses due to infection, trauma, or cancer, the body's immune system becomes highly activated in an attempt to fend off invading organisms, foreign bodies, or tumor cells.

This technique uses a drug that targets the reservoir cells and activates the virus which then allows the immune system to find these cell using the activated virus as a landmark.

The immunotherapy is designed to activate the disease - fighting immune system to attack and kill tumor cells.

TPU scientists suggest activating cell immune system with hybrid spherical microcontainers that contain antiviral RNAs (Ribonucleic Acids).

These problems are caused by a type of white blood cells called T cells that, after becoming activated, find their way into the brain and attack the protective covering — myelin — of neurons in the brain and spinal cord, causing inflammation and damage to the central nervous system.

When the immune system's T cells detect a bacterial protein, they become activated and ready to fight the intruder.