Sentences with phrase «activate cytotoxic»

Invariant natural killer T (iNKT) cells are rare helper immune cells that activate these cytotoxic cells when cancers go into hiding.

They induce CD4 + helper T cell responses, which in turn activate cytotoxic T cells and direct them to recognize and fight specific types of cancer.

Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.

Not exact matches

DAP12 plays a critical role in activating the NK cells» cytotoxic pathways; therefore, lower levels of DAP12 in NK cells results in a reduced ability to target tumor cells.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

Daniel E. Speiser and coworkers demonstrate that human cancer - specific cytotoxic CD8 T cells are strongly activated after vaccination with peptides and CpG oligonucleotides, representing the currently most powerful synthetic cancer vaccine formulation.

Target - cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes.

While cytotoxic lymphocytes are known to produce anti-tumor activity, T cell response can be modulated by activating and inhibitory co-receptors.

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.