Sentences with phrase «activate other genes»

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

Vocabularies proliferate as repressor genes, corepressors and aporepressors, modifier and switch genes, operator genes that activate other genes, cistrons and operons that constitute subsystems of interacting genes — even genes that regulate the rate of mutation in other genes — are invoked.

The guilty protein is beta - catenin, a transcription factor which activates other genes.

Not exact matches

The researchers are now investigating whether the guide RNA turns on each of these genes individually or whether it activates one or more regulatory genes that then turn the others on.

At the molecular level, RNA can bind DNA to deactivate gene segments, bind other RNA or it can bind proteins, activating or deactivating them.

Other genes activated by the guide RNA encode mitochondrial proteins that help cells regulate their energy metabolism, and trafficking proteins that are involved in packaging and transporting other protOther genes activated by the guide RNA encode mitochondrial proteins that help cells regulate their energy metabolism, and trafficking proteins that are involved in packaging and transporting other protother proteins.

A class of small molecules found in grapes, red wine, olive oil, and other foods extends the life of yeast cells by approximately 70 % and activates genes known to extend life span in laboratory animals.

The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR - gamma.

The gene known as RD26 is activated, on the other hand, when plants are challenged with drought stress, Yin said.

Independent studies by Hortelano's group and other research teams in Germany and the United States have shown that this oral gene therapy does not activate the immune system.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

They can search for other clock components by looking for proteins CLOCK interacts with and genes that it activates.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

In other words, DNA in the Hox - D region encodes timing information which ensures that the genes are activated at precisely the right moment during development.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

What's more, none of the patients experienced macrophage activate syndrome or cytokine release syndrome, an infusion reaction observed in other gene therapy trials characterized by fever, nausea, chills, hypotension or a rash.

In other organisms, there is instead a signaling mechanism: An embryonic cell receives chemical signals from neighboring cells that activate (or repress) the genes that allow for germ - line function.

It has billions of parts, many used to activate and silence genes — an arrangement that allows individual cells to specialize as brain cells, heart cells and some 200 other different cell types.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

Microglia are activated during Alzheimer's disease progression and may mediate an initially protective inflammatory response, a notion that is also supported by epidemiological studies linking mutations in the TREM2 gene to increased risk of Alzheimer's and other neurodegenerative diseases.

It's been an important question — many lung cancers depend on over-activation of the gene EGFR, but then when EGFR inhibitors like gefitinib or erlotinib are used, the cancers tend to activate other «kinases» that allow the cancer to by - pass around this dependence.

Professor Francesc Cebrià, who led the scientific study, affirms that «in other animals, genes egr are activated in immediate response processes such as inflammation, wound healing and stress.»

Mount Sinai researchers have identified six genes that activate hundreds of other genes in children experiencing severe allergic reactions to peanuts.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

When activated by the relevant light colour, these genes feed signals to other added genes that then produce visible pigment of an identical colour.

Some researchers have argued that endogenised retroviruses may be key to how species diverge from each other, by activating different body plans and gene networks that may give one individual an edge over other members of the species.

The team reasoned that they might be able to use the switch gene to activate not just tyrosinase, but a range of other genes too — for example, genes that would stimulate a stronger immune response to cancer cells.

La Vanguardia, EFE, La Sexta, RTVE, among other media, have published articles about the study by Jordi Casanova, at IRB Barcelona, that reveals that the same genes can activate tumour growth and metastasis and that therefore some tumours are conferred metastatic capacity from their very outset.

NF - κB is transcription factor that, among other functions, turns on genes involved in inflammation and immune response, and can be activated in the presence of pro-inflammatory cytokines.

They found that the transplanted cells strongly activate genes that help to guard against damage from ER stress, and suppress other genes that may trigger cellular attempts to self - destruct.

Moreover, recent data also show that in response to brain damage caused by aging, amyloid deposition, demyelination, and other insults, microglial cells activate several genes, including APOE, in order to more efficiently scavenge and clear tissue debris that are very rich in cholesterol due to the natural composition of the brain, which is mostly made of fats.

«Other genes are being activated.

Both genes act by regulating other genes involved in genetic patterning, but panish represses them while bicoid activates them.

«We now need to find out what other genes FOXM1 is activating to drive meningioma growth, and block those targets with clinical therapies,» Raleigh said.

Duesberg's career took a turn in March 1987, when he published a paper in Cancer Research that made two sensational claims: One was that retroviruses did not activate cancer - promoting genes; the other was that the newly identified HIV retrovirus did not cause AIDS.

In the current study, the researchers found that EBNA2 and its related transcription factors activate some of the human genes associated with the risk for lupus and several other autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease.

Developmental regulation proceeds through the sequential activation of a series of regulatory switches that in turn activate networks of other genes.

This gene is a switch that activates a range of other genes.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T - cell - derived lymphomas

Many of the regulatory genes that contribute to lupus and other autoimmune disorders did not interact with EBNA2, and some individuals with activated regulatory genes associated with disease risk do not develop disease.

Other often utilized technologies are fluorescence activated cell sorting, tissue culture, gene expression analysis, protein analysis, and lentiviral mediated gene transfer.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

In other words, why don't PU.1 and C / EBPα inappropriately activate neutrophil genes in the context of a macrophage, and vice versa?»

Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

These factors work together to activate genes involved in fashioning heart muscle cells, while suppressing genes characteristic of other cell types.

What other genes does HIF activate?

The vegan diet managed to activate genes responsible for preventing diseases and deactivate genes which cause different health conditions such as prostate cancer, breast cancer, heart disease, and other diseases (read more >).

Fasting, among other things, activates SIRT genes (a great cellular tune - up) and have recently been shown to trigger stem cell regeneration of the immune system.