According to this model, local control of muscle growth would be achieved by regulating the extent to which the latent form of myostatin is
activated at the target site, whereas global control of the metabolic homeostatic balance between muscle and other tissues would be achieved by regulating the size of the circulating pool of myostatin.
«We wanted to utilize platelets» intrinsic tendencies to accumulate
at wounds and to interact with circulating tumor cells, for
targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from
activated platelets in the surgical
site, due to generation of small platelet - derived microparticles upon the platelet activation.
Importantly, it's secretion from normal cells can be induced by
activating p53 so that Par - 4 enters circulation, thereby potentially
targeting tumor cells
at distant
sites.