Sentences with phrase «activated by insulin»

A key enzyme in cholesterol biosynthesis is 3 - hydroxy -3-methylglutaryl — CoA reductase (the target for statins), which is activated by insulin, which means that an increase in blood glucose and consequently of insulin levels will lead to increased endogenous cholesterol synthesis.

Since GLUT - 4 is activated by insulin, this extra efficiency will allow insulin levels to fall.

Now, Fox01 is a downstream of Akt, and if you recall, Akt can be activated by the insulin receptor signaling.

This involves the phosphorylation event typically actually activated with PI3 kinase, which is also not only activated by insulin, but also it can be activated by leptin.

Not exact matches

By removing an attached string of amino acids, the enzyme activates hormones such as insulin and two hormones that may play a role in obesity — glucagonlike peptide 1 and melanocortin - stimulating hormone.

In a healthy mother, this enzyme is activated by hormones like insulin and insulin - growth factors (IGFs), kick - starting a relay race within cells which stimulates nutrient uptake and, as a result, normal growth and metabolic function.

FoxO1 acts as a sensor of blood sugar levels and responds by activating insulin production.

Our vigorous genetic approach combined with direct observations of Dilp production in IPCs provides the first evidence, to our knowledge, that Bombesin - related receptor signaling activated by its endogenous ligand promotes insulin production.

This is quite a complex pathway and I don't have time to go through details, but just briefly, glucose metabolism is regulated by insulin, so is lipid metabolism and this is one of many pathways where insulin activates a number of kinases, but particularly Akt.

It's actually a very important transcription factor that's regulated by insulin, and this is involved in activating genes involved in fatty acid synthesis and so - called lipogenesis, which is synthesizing new lipids and this is, therefore, important in lipid metabolism.

Specifically, it works by activating glucagon, which works in opposition to insulin to keep your blood glucose levels balanced.

A sustained modest weight - loss of five to 10 % body - weight is associated with improvements in various indices of cardiometabolic health including but not limited to insulin sensitivity, vascular function, blood pressure and lipid levels.3 These beneficial effects of weight - loss can be partially explained by accompanying reductions in adipose tissue mass and dysfunction.5 There is however, some evidence to suggest that energy restriction (ER) alone can confer metabolic changes which are independent to those of weight - loss, by facilitating an acute negative energy balance 6 - 9 and / or by activating adaptive stress response pathways.10

Stimulation of beta - amyloid precursor protein trafficking by insulin reduces intraneuronal beta - amyloid and requires mitogen - activated protein kinase signaling.

Insulin molecules are highly vulnerable to oxidation — attack by free radicals — and this makes them less effective at activating glycogen stores.

Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.

«There are multiple interactive pathways and molecular mechanisms by which CR (calorie restriction) and IF (intermittent fasting) benefit neurons including those involving insulin - like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator - activated receptors.

Engagement of the Insulin - sensitive Pathway in the Stimulation of Glucose Transport by Alpha - lipoic Acid in 3T3 - L1 Adipocytes Diabetologia 2000 (Mar); 43 (3): 294 — 303 These results indicate that R (+) alpha - lipoic acid directly activates lipid, tyrosine and serine / threonine kinases in target cells, which could lead to the stimulation of glucose uptake induced by this natural cofactor.

Exercise increases insulin sensitivity and, if it's intense enough, can even activate something called non-insulin dependent glucose uptake, which is a method for increased glucose uptake by the muscles without using insulin at all.

Furthermore, available evidence from in vitro studies suggests that one of the possible mechanisms through which phthalates exposure may affect insulin sensitivity is oxidative stress, either by activation of peroxisome proliferator — activated receptors (20) or by changes in mitochondrial membranes potential and permeability (21).