This involves the phosphorylation event typically actually activated with PI3 kinase, which is also not only activated by insulin, but also it can be
activated by leptin.
I've mentioned previously JAK2 is the kinase that's
activated by the leptin receptor, and that leads to recruitment and activation of the STAT3.
Not exact matches
STAT3 is a major adaptor, or actually it's a transcription factor that's
activated by JAK2 kinase, and this leads to a so - called
leptin signal, and the
leptin signaling cascade.
«What we're doing in phase two and three,
by lowering calories and eating only certain foods, is trying (1) to get the SIRT1 gene
activated, which is an anti-ageing gene naturally
activated by exercise and restricted calorie intake, and (2) get
leptin to be reduced
by the amount of fat you're burning and get you to a point of
leptin sensitivity again» says O'Meara.
For example, fiber is metabolized
by our gut flora into short - chain fatty acids, which bind to and
activate receptors on the surface of our cells that alter our metabolism, for example,
activating receptors on fat cells to increase the expression of the weight - reducing hormone,
leptin.