Sentences with phrase «activated cell signaling pathways»

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The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.

Protein interactions between niche glial cells and the stem cells activate the Hippo signaling pathway in the stem cells to repress growth and cell division.

Meanwhile, fertilisation of the egg cell activates its «ethylene signalling» pathway, which degrades the nucleus of the persistent synergid cell.

Normally, when the body detects an outside invader such as a virus, a signalling system known as the PKA pathway responds by turning on 99 genes that then activate T - cells to destroy the invader.

Like a cascade, after the first molecule in a pathway receives a signal, it activates another molecule and so forth until the cell function is carried out.

In order to keep step with the «quickened» mitochondrial translation, somatic cells activated the mTOR signaling pathway in order to accelerate cytoplasmic translation and balance mitochondrial translation.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

«This detection activates cell - signaling pathways that produce antimicrobial peptides, suppress the growth of harmful bacteria, and maintain the integrity of the intestine's epithelial barrier.

STAR2 works by specifically binding to a cell surface protein called TNFR2, activating a signaling pathway that increases the number of T reg cells.

Dr. Veenstra joined NCI - Frederick in the fall of 2001 to implement a state - of - the - art mass spectrometry center that focuses on the discovery of signaling pathways and networks that are activated within cells as a response to external perturbations.

It locks onto and deactivates a protein, Smoothened, that activates the Hedgehog signaling pathway, which orchestrates how embryonic stem cells develop.

A metabolic pathway that is up - regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biolcell signaling protein called Arf6, according to a paper published in the Journal of Cell BiolCell Biology.

Independently of Smads, BMP signaling also activates the p38 MAPK pathway (32 — 34); however, additional assays in COS - 7 cells showed no increase in p38 MAPK phosphorylation in response to ACVR1 (R206H)(data not shown).

Interestingly, a previous STEM CELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cCELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cellscells.

Cortex Mori Radicis Extract induces neurite outgrowth in PC12 cells activating ERK signaling pathway via inhibiting Ca2 + influx.

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

To prevent this from happening patients are treated with a second compound that stops this cell signaling pathway from being unintentionally activated.

The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.

Studies have shown that exposure of tumor cells to therapeutic doses of radiation activates cell survival signaling pathways such as EGFR - RAS [2 - 5] and its downstream molecules such as ERK1 / 2, PI3K - AKT, JNK, etc. apart from several other signaling molecules [4, 6, 7].

Quantitative Single - Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.

Ionizing radiation has been shown to activate these signaling pathways in different intensities and in a cell type - dependent manner [6].

A Emory News item on a helpful part of the microbiome focuses on how the same type of bacteria â $ «lactobacilli â $ «activates the same ancient signaling pathway in intestinal cells in both insects and mammals. It continues a line of research from Rheinallt Jones and Andrew Neish on how beneficial bacteria stimulate wound healing by activating ROS (reactive oxygen species).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

To explore if Hedgehog signaling also has an effect on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in fat cells would activate when they ate a high - fat diet.

What drove the motility response in T cells was synthesis of hydrogen peroxide, which then activated a signaling pathway that increases Tcell movement.

The first aim of this study is to dissect the signaling pathways activated downstream of TLR2 by CEP in the various cells local to the retina.

1) The results of the inhibition of miR -142-3p in the human breast cancer xenograft cells and the Wnt signaling pathway inhibition in human breast cancer cells have confirmed that our finding that miR - 142 targets APC, activates the Wnt signaling pathway and upregulates miR - 150 is applicable to human breast cancers.

IL7R is expressed in HCC but not in normal liver cells, and can activate JAK2 to increase cell growth.57 SOCS3 is a negative regulator of the JAK / STAT signalling pathway, and can inhibit JAK2 itself.58 Therefore, inhibition of JAK2 by SOCS3 could result in decreased proliferation.