Sentences with phrase «activated cell stress»

Professor Howell, based at the Genesis Breast Cancer Prevention Centre at University Hospital of South Manchester, and at The University of Manchester, said: said: «At least 50 per cent of cancer risk is genetic, but activated cell stress signalling could potentially be reduced by dietary or lifestyle intervention.

Not exact matches

But, in mice where the gene couldn't be activated in the gut, TH17 cells that were exposed to bile acids suffered severe oxidative stress.

The noise - intolerant timer typically keeps the competence switch closed, but when the cell is exposed to stress over a long period of time, the timer activates a decision gate that opens brief «windows of opportunity» in which the competence switch can be flipped.

Drugs that activate this novel stress response pathway, which they call the mitochondrial - to - cytosolic stress response, protected both nematodes and cultured human cells with Huntington's disease from protein - folding damage.

In a series of cell - based studies, they showed that it both blocked a family of iron - containing, oxygen - sensing enzymes called hypoxia - inducible factor prolyl - hydroxylases (HIF - PHD) and, critically, protected neurons by activating genes that protect them from oxidative stress.

Scientists at The Institute of Cancer Research (ICR) used the cells of fruit flies, modified with a fluorescent marker that is activated when the cells are put under stress, to identify the signals responsible for driving up activity of the ER.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.

The stress hormone treatment activated a protein called FAK (focal adhesion kinase), which is known to protect cells from anoikis.

For instance, it is conceivable that T cells activated in the absence of type 1 interferon reveal themselves as being «stressed» and are thus killed off.

a defensive strategy that cells can activate when in danger or under stress.

But how p53 shakes off its negative regulators when cells experience one of the myriad stresses that activate p53 has been the topic of much discussion.

They found that the transplanted cells strongly activate genes that help to guard against damage from ER stress, and suppress other genes that may trigger cellular attempts to self - destruct.

Hydrocarbons Adsorbed to Combustion - Derived PM Localize to Lipid Droplets and Activate Oxidative Stress Response Genes In Respiratory Cells (128910).

LKB1 acts as a key regulator of cell polarity as well as energy metabolism partly through the activation of the AMP - activated protein kinase (AMPK), a sensor that adapts energy supply to the nutrient demands of cells facing situations of metabolic stress.

When the virus is activated by hormones or stress on the neurones, it leaves its host neurone cells intact but travels down the nerve to the skin.

Discovered in the late 1970s, the mechanism, called the unfolded protein response, relies on communication between the ER and the cell nucleus: When misfolded proteins, which can cause stress - related diseases, accumulate in the ER, cells counter the surge by triggering a program of gene expression in the nucleus that raises the abundance of ER proteins that foster protein folding and activates a mechanism that degrades protein clumps.

«This work suggests that activating autophagy to help rid cells of stress granules offers a new approach to neurodegenerative disease treatment,» Taylor said.

When cells had mutations in NOTCH1, however, shear stress failed to protect the valve and, instead, the cells activated a detrimental gene program that drives bone formation.

From other papers I would like to highlight the one by M. Mehrshad and enigmatic SAR202 cluster, the one by A. C. Lehours and biogeographic patterns of aerobic anoxygenic phototrophic bacteria and the one by E. M. Llufrio and how fluorescence activated cell sorting introduces oxidative stress and alters the metabolic state of cells.

The agreement is focused on modulators of the Integrated Stress Response (ISR), a set of processes activated in cells under conditions of sStress Response (ISR), a set of processes activated in cells under conditions of stressstress.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

When you stress, you secrete excess cortisol, activating fat - storage enzymes in cells, which can lead to that dreaded spare tyre.

MAPKs (Mitogen - Activated Protein Kinases), which help the cell to respond to stress and inflammation, are vital in nature, but also regulate gene expression and survival.

The acutely stressed group actually had greater numbers of activated T cells, lower cancer incidence and fewer numbers of skin tumors.

In a notable example of this web - like communication, perceptions of stress can activate monocytes in the bone marrow that then feed back to sensitize the brain and its resident immune cells to further the stress response.

Also, stress can activate more of these cells.

It should be noted that the transit time from mouth to activating muscle cell growth ranges from 24 to 72 hours, depending on age, gender, genetic predisposition and individual fitness response to exercise stress.

JNK is a stress - activated protein kinase, or a SAPK, that plays a roll in everything from gene expression, to cell death, to energy production.

-RCB- elevated sodium level within kidneys, either as a result of pathological bottleneck such as reduced number of nephrons, or simply due to heightened intake - or both - may activate pro-inflammatory cytokines and chemokines in proximal tubular cells, may cause oxidative stress by activating ROS - producing NADH oxidase enzymes, or blood vessel constriction by inhibiting kidney arginine transport and nitric oxide synthesis; elevated renal inflammation, oxidative stress and restricted blood flow all can impair the efficacy of sodium excretion, more so combined (if extensive, it can also result in post-natal reduction of nephron units)

Stress - activated cortisol bombards the memory center, killing nerve cells in the hippocampus, and attacks the immune system, which often causes depression and anxiety.