We determined the x-ray structure of the human BK Ca2 + gating apparatus at a resolution of 3.0 angstroms and deduced its tetrameric assembly by solving a 6 angstrom resolution structure of a Na + - activated homolog.
On the other hand; neuroblastoma RAS Viral Oncogene Homolog (NRAS) mutation is known to activate BRAF which results in an anarchic melanocyte growth [30, 31].