Although the immune system is
activated on a high fat diet, the immune system is less active when you really need it, according to the study.
Not exact matches
After eight weeks
on a
high -
fat diet, mice that had been engineered with genes to
activate the Hedgehog signaling pathway didn't gain weight (left), but control animals whose Hedgehog pathways were not
activated became obese (right)(Credit: Long Lab)
Over an eight - week period, a control group of mice fed a
high -
fat diet predictably became obese, but the mice whose Hedgehog pathway had been
activated didn't gain any more weight than another control group fed
on a normal
diet.
To explore if Hedgehog signaling also has an effect
on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in
fat cells would
activate when they ate a
high -
fat diet.