Sentences with phrase «activates fibroblasts»

The inflammatory processes also activate fibroblast - like synoviocytes (FLS), specialized cells that line the inside of joints providing lubrication and repairing joint injuries.

Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

Not exact matches

However, 2 years ago, Terry Smith of the Harbor - University of California, Los Angeles, Medical Center in Torrance and colleagues discovered that in patients with Graves disease — an autoimmune disorder that attacks the thyroid gland and eyes — fibroblasts make chemokines when so - called immunoglobulin G antibodies in the blood activate a protein called the insulin - like growth factor 1 (IGF - 1) receptor.

The orbital remodeling in TED is likely induced by infiltrating T lymphocytes and mast cells, which activate orbital fibroblast effector cells to either proliferate and form scar - producing cells called myofibroblasts or turn into pro-inflammatory fat cells.

- catenin pathway activates certain lncRNAs to directly control gene expression in skin fibroblast cells.»

This signature showed that a cellular communication network called JNK1 was activated to a greater extent in fibroblasts from high density breast tissue.

↵ 3 The abbreviations used are: HUVEC, human umbilical vein endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated cell sorting; FGFR, fibroblast growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.

Fibroblasts were activated and highly proliferative, reaching a maximum rate within 2 to 4 days after infarction injury, at which point they expanded 3.5-fold and were maintained long term.

The new fibroblasts in the scar are activated and adopt a smooth muscle actin — and periostin - positive «myofibroblast» phenotype, which appears to last as long as the scar is not mature (~ 10 days after MI).

The Joslin researchers «reprogrammed» the fibroblasts into iPSCs by using viral procedures that activated four genes that together maintain cells in the iPSC state.

MAIT cells are activated and secrete Interferon - g after stimulation by fibroblasts or antigne presenting cells co-cultured with bacteria and yeasts but not viruses.

Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53 - independent but extracellular signal - regulated kinase - p38 mitogen - activated protein kinase - dependent mechanism.

Together, Myc and Gcn5, a histone acetyltransferase, reprogram fibroblasts to a stem cell state by activating an alternative splicing network.

Fibroblast growth factor - 2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS.

Results: Fibroblast growth factor 2 (FGF2) treatment reduced expression of β - cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3.

Fibroblast growth factors activate mitogen - activated protein kinase pathways to promote migration in ovine trophoblast cells

At the same time, the protein Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem Cell Factor (SCF) stimulates your native inactive stem cells to become activated and assist in the repair of the damaged tissue.