Sentences with phrase «activating osteoclasts»

«The cancer cells can specifically activate the osteoclasts for bone degradation,» Wu said.

Previous studies suggest that microgravity activates osteoclasts, cells that control the breakdown of bone tissue, and the Medaka fish investigation examined the relationship between this increased osteoclast activity and reduced bone mineral density.

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.

Vitamin A activates osteoclasts that disrupt these bony surfaces to stimulate growth27.

Not exact matches

The role of calcium release activated calcium channels in osteoclast differentiation.

4 - 1BBL was largely thought to be on APC that have been activated for several days, such as dendritic cells, B cells, and macrophages although again it is clear that 4 - 1BBL is now more ubiquitous as it has been visualized to be induced on diverse cell types such as mast cells, osteoclasts, smooth muscle, and stem cells.

It stimulates the production of calcitonin, the hormone responsible for inhibiting cells (osteoclasts) that breaks bone down and activates alkaline phosphatase, an enzyme that forms new calcium crystals in bones.