Sentences with phrase «activating point mutations»

In this study, we show that 80 % of the autonomous BaF3 clones, selected in our in vitro model, acquired activating point mutations in the kinase or pseudokinase domain of JAK1.

Not exact matches

Altogether, beside the mutations targeting the JH1 / JH2 interface, the other activating mutations found in this study point to two other hotspots for the regulation of JAK enzymatic activity: the hinge region and in the loop formed between β2 - and β3 - strand in the kinase domain.