Sentences with phrase «activation mechanisms»

Due to the controversial nature of these changes, there are several different activation mechanisms in play.

Distinct c - Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.

The scientists describe in the online edition of the journal Nature Structural and Molecular Biology the molecular details of this activation mechanism and the enzymes responsible for it.

But with the design of each well's membrane and activation mechanism, Langer says, «I don't think there are big safety concerns.»

Using the nanodiscs, the team elucidated the activation mechanism of receptor kinase AgrC and discovered a key regulatory hotspot in the kinase that could greatly affect its activity.

Our study reveals a new activation mechanism for protein kinases, which should be considered in the design of drugs that target PKG I,» said Kim.

Kim and colleagues are interested in studying the activation mechanism of protein kinase G I (PKG I) because a mutation of PKG I has been shown to cause thoracic aortic disease, as Kim and his collaborators showed in a previous publication in the American Journal of Human Genetics.

A self - propagating activation mechanism of downstream inflammasome signaling starts with one molecule of NAIP4 directly binding its microbial ligand.

Remarkably, the scientists found that the two endolysins share this common activation mechanism, despite being taken from different species of Clostridium.

By studying recurrent somatic SVs affecting intergenic regions, we recently demonstrated that «enhancer hijacking» — the juxtaposition of active enhancers near proto - oncogenes, and often across topological association domain (TAD) boundaries — is a frequent oncogene activation mechanism in solid tumors (Figure 2).

Working with Sebastian Lourido and David Sibley, we used these structures to discover that the activation mechanism of CDPKs involved a dramatic refolding and movement of the calcium domain [Wernimont et al, Nature Struct.

We decided that it's always better not to depend on mail service providers and implemented Reverse activation mechanism for your members.

See better registration attempts to registrations conversion with the new and enhanced reverse activation mechanism.

Hilliard proposed a slightly complex but clever solution that would make everything compatible: Segregated Witness activation as proposed by the Bitcoin Core development team, the BIP148 UASF and the New York Agreement activation mechanism.

Furthermore, Bitmain added that it did not intend to execute hard fork if the mining community, industry, and users came together and agreed on one activation mechanism — Segregated Witness (SegWit).

Not exact matches

Capsaicin induces the sustained activation of EGFR downstream signals through the induction of EGFR transactivation mediated through Src and MMP - dependent mechanisms.

Above all, mechanism / processes for the establishment and activation of inter community vigilante groups would be established by the civil power in Ebonyi State to help to de-escalate tension and address emerging security challenges across the communities and its environs.

Soluble CD14 levels were inversely correlated with measures of bone mineral content and density, suggesting macrophage activation as a possible mechanism for such bone loss.

But the activation is not as strong as that caused by real pain because inhibitory mechanisms normally dampen the response.

So you can see a very clear mechanism whereby people with chronic immune activation can become depressed.»

In the current study, Lee set out to understand the mechanism underlying the activation of brown fat.

Importantly, knowing the mechanism by which retinoids reduce CK5 activation now leads the team to a hypothesis that could stop this activation.

Model of a glycoprotein hormone receptor (white backbone ribbon) with bound hormone and the activating antibody visualizes a potential arrangement and the principle mechanism of glycoprotein hormone receptor activation.

Their results demonstrated shared mechanisms by which miR -17-92 mediates cGVHD progression — namely by regulating T helper - cell differentiation, B - cell activation, germinal center responses, and autoantibody production.

Researchers at CSHL have discovered a new fail - safe mechanism that prevents transposon activation even when the inactivating marks have been erased.

The underlying mechanism involves the activation of the immune system, resulting in local inflammation and proliferation of skin cells.

Reasoning that direct insertion of a metal into the bond would face too high an energy barrier, the authors implemented a dual activation strategy, targeting a mechanism in which gold coordination enhances the reactivity of the C - C triple bond while trifluoroacetate coordination to B stimulates transfer of the adjacent O group.

«Study reveals mechanism behind enzyme that tags unneeded DNA: Essential DNA packing enzyme relies on 2 - step activation to ensure correct genetic organization.»

Their work elucidates a dynamic, two - step mechanism in females whereby B cells lacking the markers of X chromosome inactivation regain these modifications during B cell activation, in a process involving the transcription factor YY1.

«Because of the important role of UPR in regulating cell life / death decisions, it is critical that mechanisms are in place to prevent unnecessary UPR activation in response to innocuous or low - level stimuli,» said Wilkinson.

«Future investigation of the exact mechanisms responsible for activation of this interesting circuit may provide insights into autism spectrum disorder and other social behavioral disorders.»

The structure of this transcription factor — DNA complex provides insights into possible mechanisms of transcription activation.

Thompson is the corresponding author for the journal article, «Molecular Characterization of Latent GDF8 Reveals Mechanisms of Activation,» and its first author, Ryan Walker, is a postdoctoral fellow at Harvard University and a former UC doctoral student who once worked in Thompson's laboratory.

The research uncovers some of the mechanisms that drive the rapid activation of neutrophils, says immunologist Andrew Gelman of Washington University School of Medicine in St. Louis.

«Our results have revealed and characterized two classes of GGAA - microsatellites that suggest unique interactions and distinct regulatory mechanisms for distance - dependent activation and repressions.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

These trigger the activation of a number of defense mechanisms.

In a study of preclinical models of colorectal cancer, the researchers identified an underlying mechanism for the activation of p53 by FL118.

In the example quoted here, a mechanism composed of seven steps was proposed: It should have seven sets of activation parameters instead of the single activation energy calculated in the Report.

They found that DOCK7 activates ErbB4 through a previously unknown mechanism; this activation must occur if chandelier cells are to develop their characteristic architecture.

«Surprisingly, we found that calcium avoidance occurred through two mechanisms: activation of a unique class of GRNs, distinct from those that sense bitter compounds and which cause a stop - feeding signal when activated.

The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.

Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.

But as Hermeking explains, «Activation of IL - 6R upon binding of IL - 6 essentially disables this inhibitory mechanism.

There he studied the fundamental cellular and biochemical mechanisms required for immune cell activation and clearance of infections.

«The mechanism that we have now identified regulates body fat mass independently of leptin, and it possible that leptin combined with activation of the internal body scales can become an effective treatment for obesity,» says Professor Claes Ohlsson at Sahlgrenska Academy, Gothenburg University.

In addition, other mechanisms are likely contributing to TrkB activation in both memory and epileptic episodes, and McNamara's group is exploring other potential mechanisms.

«Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state of chronic immune activation and systemic inflammation seen in these patients,» said Dr. Jabs.

This decreased reward response to alcohol arose via two mechanisms: an initial activation of stress hormone receptors and a subsequent increase in inhibitory signaling in the brain.

«This is not, in my mind, an approach to take during chronic infection, because once infection has been established, the mechanisms of immune activation become much more complicated,» observes Martin Markowitz, staff investigator at the Aaron Diamond AIDS Research Center in New York City.