Sentences with phrase «activation of activator»

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Not exact matches

«In the case of glycoprotein hormone receptors, the family of proteins that includes the thyroid receptor, upon binding of the extracellular hormone, the intramolecular activator (p10) induces structural changes of the receptor protein, triggering activation of the intracellular signaling cascade.»

CED - 4 translocation induced by the cell - death activator EGL - 1 was blocked by a gain - of - function mutation in ced - 9 but was not dependent onced - 3 function, suggesting that CED - 4 translocation precedes caspase activation and the execution phase of programmed cell death.

The structure determined by the Rutgers researchers is the structure of a transcription activation complex containing the TTHB099 activator protein (TAP) from the bacterium Thermus thermophilus.

For instance, generally, the more highly expressed a gene is under native conditions, the less activation you can achieve using a Cas9 activator; your gene of interest might already be hitting an upper bound of activation that current Cas9 systems can not help you pass.

This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300 / CBP HAT activation has neurotrophic effects in a cellular model of PD.

Activators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapiActivators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapiactivators as drug therapies for PD.

Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATINof Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATINof Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATINof STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATINOF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN M