Sentences with phrase «activation of adenosine»
Interestingly, it has been suggested that the initial signal responsible for triggering the development of hypoxic preconditioning in the brain involves the opening of ATP - sensitive potassium channels via the activation of adenosine A1 receptors [69].
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Reactive Oxygen Species Precede Protein Kinase Cd Activation Independent of Adenosine Triphosphate — sensitive Mitochondrial Channel Opening in Sevoflurane - induced Cardioprotection.
Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.
The adenosine A ₂ ₐ receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells and binding of adenosine to the A ₂ ₐ receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.
In order for this activation to take place, the enzyme methionine adenosyltransferase (MAT, also known as S - adenosyl methionine synthetase) breaks apart ATP to harvest from it a molecule of adenosine and then activates methionine by sticking adenosine onto it.
More recent research describes adenosine as «a mediator with multisystemic effects», and it is produced by almost all cells, playing a role in heart function, sleep, bone health, activation of the immune system and mediating the effect of various hormones.