A vascular injury model using focal heat - induced
activation of endothelial cells.
The adaptor CRADD / RAIDD controls
activation of endothelial cells by proinflammatory stimuli.
Activation of endothelial cells elicits a complex series of responses that include the elaboration of proteolytic enzymes, migration, and proliferation.
Not exact matches
The onset
of angiogenesis appears to be the result
of an imbalance between stimulatory and inhibitory factors that leads to the
activation of previously quiescent
endothelial cells (4, 5).
Hyperosmolarity attenuates TNF - α — mediated proinflammatory
activation of human pulmonary microvascular
endothelial cells.
Release
of cytochrome c, Bax migration, Bid cleavage, and
activation of caspases 2, 3, 6, 7, 8, and 9 during
endothelial cell apoptosis.
Receptor - mediated
activation of nitric oxide synthesis by arginine in
endothelial cells.
Increased MAPK
activation and impaired insulin signaling in subcutaneous microvascular
endothelial cells in type 2 diabetes: the role
of endothelin - 1
From these
cell based and clinical studies, we have developed important mechanistic ideas such as
activation of protein kinase C, the role
of vascular
endothelial growth factor (VEGF) and selective insulin resistance as some
of the basic mechanisms for the pathogenesis
of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
Josin researchers made two major findings: They identified the mechanisms by which GLP - 1 can induce protective actions on the glomerular (renal)
endothelial cells by inhibiting the signaling pathway
of Ang II and its pro-inflammatory effect; and demonstrated a dual signaling mechanism by which hyperglycemia, via PKCβ
activation, can increase Ang II action and inhibit GLP - 1's protective effects by reducing the expression
of GLP - 1 receptors in the glomerular
endothelial cells.
Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers
of atherosclerosis.94 In another study, human coronary artery
endothelial cells were exposed to the smoke equivalent to one cigarette, which led to
activation of oxidant stress sensing transcription factor NFR2 and up - regulation
of cytochrome p450, considered to have a role in the development
of heart disease.95 These effects were not seen when heart
cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain
cells.96
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN
of Signal Transducer and Activator
of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN
of Transcription 1 (STAT1) Is Not Sufficient for the Induction
of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN
of STAT1 - dependent Genes in
Endothelial Cells: COMPARISON
OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN
OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN M
Elevated plasma concentrations
of soluble forms
of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the
endothelial cell surface, are considered useful indicators
of endothelial dysfunction and
activation (20, 25).
Ishikado, A. Sono, Y. Matsumoto, M. Robida - Stubbs, S. Okuno, A. Goto, M. King, G. Blackwell, K. Makinoa, T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through
activation of Nrf2 in vascular
endothelial cells and Caenorhabditis elegans.
Linoleic acid induces proinflammatory events in vascular
endothelial cells via
activation of PI3K / Akt and ERK1 / 2 signaling
Activation of Nrf2 in
endothelial cells protects arteries from exhibiting a proinflammatory state.