Sentences with phrase «activation of that gene in»

Goats as Drug Factories Initially, GTC generated transgenic goats by microinjecting into the developing nucleus of a one - cell embryo a gene encoding the desired human protein (along with DNA that promotes activation of that gene in milk).

«We generated DNA sequences consisting of the gene, either MIZ1 or SnRK2.2, with different «switches» to control the activation of the gene in specific layers of the root,» Nottingham's Daniela Dietrich explains to New Atlas.

Not exact matches

Additionally, turmeric has been shown to act on the liver to regulate epigenetic (activation of genes) and enzymatic factors that all work together to stabilize blood sugar and triglyceride levels in people with diabetes.

Xie et al. report that STING (stimulator of interferon genes)-- the main adaptor in several DNA - sensing pathways — is mutated in bats at the serine - 358 residue, which is critical for downstream interferon (IFN) activation.

In a common subtype of acute myeloid leukemia, this abnormal activation of such self - renewing genes is apparently caused by structural modifications of the DNA packaging.

This action can result in the activation of genes that had been switched off, and could be the cause of the recovery of synaptic strength.

Yet, in this plant (as well as in certain conifers), the researchers found genes similar to those responsible for the formation of flowers, and which are organized according to the same hierarchy (with the activation of one gene activating the next gene, and so on)!

«In contrast to RNA interference, which is commonly used to inactivate gene activity, the CRISPR - on system allows activation of cellular genes.

Gene activation was also reversed in the oocytes of TGF - β mutants.

She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the cell - cycle regulated HO gene in the yeast Saccharomyces cerevisiae.

They found that gene expression is different at 209 sites in chronically lonely people and that many of those changes fit a pattern of elevated immune activation, inflammation, and depressed response to infection.

Murphy found that the normal pattern of gene activation seen in aging wild - type C. elegans was reversed in the body cells and oocytes of IGF - 1 mutants.

The scientists have shown that, in all cancers, an aberrant activation of numerous genes specific to other tissues occurs.

This program, resulting in shorter 3 ′ UTRs, is a characteristic of gene expression during immune cell activation and correlates with proliferation across diverse cell types and tissues.

The researchers used valproic acid which can induce the activation of such deactivated genes in fungi.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

The theory holds that histone proteins, which combine with DNA to form chromosomes, are more intimately involved in gene expression than their general role of facilitating or hindering gene activation suggests.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

Trithorax - like group complex containing KDM6A acts antagonistically to Polycomb - repressive complex 2 (PRC2) containing EZH2 in maintaining the dynamics of the repression and activation of gene expression through H3K27 methylation.

«The discovery of these aging hot spots in the genome lets us assume that the genes within these regions are somehow coordinated in their activation or de-activation,» comments Alessandro Cellerino.

Activation of NOTCH1 by blood flow causes a domino effect, triggering numerous other genes in the network to turn on or off, resulting in suppression of inflammation and calcification.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

Kaufman and colleagues engineered the fish so that individual cells would light up in fluorescent green if a gene called crestin was turned on — a «beacon» indicating activation of a genetic program characteristic of stem cells.

The team recently received an internal campus grant to use the method to control gene activation in specific regions of the brain.

The researchers tested whether HDACis, which promote long - lasting activation of genes involved in learning and memory, could help replace old traumatic memories with new memories.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itselIn fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itselin PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

In mice that gorged and then fasted, the researchers saw elevations in inflammation, higher activation of genes that promote storage of fatty molecules and plumper fat cells — especially in the abdominal area — compared to the mice that nibbled all daIn mice that gorged and then fasted, the researchers saw elevations in inflammation, higher activation of genes that promote storage of fatty molecules and plumper fat cells — especially in the abdominal area — compared to the mice that nibbled all dain inflammation, higher activation of genes that promote storage of fatty molecules and plumper fat cells — especially in the abdominal area — compared to the mice that nibbled all dain the abdominal area — compared to the mice that nibbled all day.

Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.

This pharyngeal gene cluster contains six genes ordered in a common pattern in all deuterostomes and includes the genes for four proteins that are critical transcriptional regulators that control activation of numerous other genes.

What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the activation of macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.

The analysis also showed that the preponderance of host responses shifted rapidly from activation of genes involved in cell damage and inflammation toward those linked to promotion of cellular and organ repair.

In trying to understand the sequential activation of the Hox - D genes, Duboule has come up with the novel idea that the timing is linked to the arrangement of the genes within the clusters.

Rutgers University scientists have discovered the three - dimensional structure of a gene - specific transcription activation complex, providing the first structural and mechanistic description of the process cells use to turn on, or activate, specific genes in response to changes in cell type, developmental state and environment.

Concurrently, this dermal cell aggregation triggers the mechanosensitive activation of β - catenin in adjacent epidermal cells, initiating the follicle gene expression program.

Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at the National Institutes of Health (NIH) in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to infection.

«The paper provides a dazzling snapshot of the process of transcription activation — the process whereby a gene is turned on in response to an instructive signal from the environment,» said Ann Hochschild, professor of microbiology and immunobiology at Harvard Medical School, who also was not part of the study.

Using gene therapy to insert the gene, they expressed the synthetic gene in adult mice or in zebrafish embryos, and witnessed remote activation of neurons the presence of a magnetic field through the altered behavior of the animals.

The resulting papers published in Nature all tell similar stories of shared evolution between species — for instance, the commonalities of regulatory networks of genes and the transcription factors that control their activation.

The investigators also measured gene expression of postvaccinated cervical cells in three of the patients and found increased expression of several genes (CXCR3, Tbet and IFNβ) associated with activation of the immune system.

«In that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane sayIn that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane sayin the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane says.

The infection rapidly turned on a wide range of genes involved in immune system activation and cell death, they conclude, bolstering the hypothesis that the greatest harm may not have been done by the virus itself, but by an over-reactive immune system.

In fact, these proteins can both repress and facilitate activation of many genes

These and other daily rhythms are thought to be driven by oscillations in the activation of «morning genes» and «evening genes.»

The researchers also compared patterns of gene activation in organoid cells to a database of human brain genetic information.

Profiling the expression patterns of host genes revealed that the insect significantly increases the abundance of B vitamin transporters and activation enzymes when reared in the absence of its gut microbes.

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

The «epi - marks» that adjusted parental genes to resist excess testosterone, for example, may alter gene activation in areas of the child's brain involved in sexual attraction and preference.

Using gene therapy to insert the gene, they expressed the synthetic gene in adult mice or in zebrafish embryos, and witnessed remote activation of neurons in the presence of a magnetic field through the altered behavior of the animals.

A joint study by University of Colorado Cancer Center and Memorial Sloan Kettering Cancer Center published in the Journal of Thoracic Oncology shows two distinct causes of HER2 activation in lung cancer: mutation of the gene and amplification of the gene.

In addition to reevaluating how histones control gene activation, the study also reports a new mechanism of PARP1 regulation.