B12 might also be high due to
an active MTHFR mutation along with an active COMT mutation, so patients tend to avoid the synthetic supplemental version of B12 called cyanocobalamin and instead favor the methylcobalamin (methylB12) or adenosylcobalamin (also the active form, but used by your mitochondria), but they will need adequate folate supplementation.
Having
an active MTHFR mutation can make it worse.
Not exact matches
Another common misdiagnosis is the
MTHFR mutation which is gene responsible for the conversion of folate to its
active form methyl - folate.
MTHFR is an enzyme that converts inactive folate into the
active form called 5 - methyltetrahydrofolate (5 - MTHF).