«While ChIP - seq is very powerful in that it can query an entire genome for characteristics associated with enhancer
activity in a single experiment, it can fail to identify some enhancers and identify some sites as being enhancers when they really aren't,» says Diane Dickel, a geneticist with Berkeley Lab's Genomics Division and member of the SIF - seq development team.
Not exact matches
Monkeys typically find other monkeys impossible to ignore, and this
experiment was no exception: the monkeys often failed at the reward task because they looked at the faces, especially if the faces depicted emotion.When humans are torn between paying attention to two different things, it triggers a «conflict» circuit
in a brain region called the dorsal anterior cingulate cortex (dACC) which is part of a larger brain structure controlling rational thought and emotions.Using a tiny sensor implanted
in the dACCs of the monkeys, Platt's group was able to measure the electrical
activity of
single neurons.
«This study provides proof - of - concept
experiments,
in large animal models, that a small, miniaturized device can be safely implanted
in the brain and provide miniaturized control of the electrical
activity and function of
single neurons or small groups of neurons.
Either the
activity could not have been done (e.g., as when collecting real - time data with a probe) or it could not have been done
in the available time (e.g., replicating
experiments in a
single class period).