Sentences with phrase «activity in cancer cells»

For example, patients could be referred to the most appropriate treatment according to the level of GFI1 activity in their cancer cells.

Because Akt is an important factor in the differentiation and immune function of T cells, and previous studies showed that VPA and other HDAC inhibitors could inhibit Akt activity in cancer cells (41, 42), we examined whether Akt activity was modulated by VPA treatment.

To cite a few instances, polymerase chain reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.

After all, cancer cells rely heavily on SRCs to delicately orchestrate a wide range of cellular events, so SRC stimulation might be just as effective as SRC inhibition at disrupting the balance of signaling activity in cancer cells.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

Not exact matches

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

Curcumin in turmeric has the ability to modulate genetic activity and expression — both by destroying cancer cells and by promoting healthy cell function.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

They are also testing inhibitors of JAK2, a molecule that influences ADAR1 activity, for their ability to eliminate cancer stem cells in multiple myeloma models.

Cancer cells may produce unique metabolic profiles, in part because they grow very rapidly and have metabolic activity very different from normal cells.

The drug that they have developed appears to target cancer stem cell activity, which suggests it will prevent metastatic recurrence and be useful in combatting drug resistance.»

Genes with increased activity are in metabolic pathways that allowed cancer cells to bypass BRAF altogether and continue to grow and divide.

In pancreatic cancer, their activity boosts tumor growth and spread, and may also help suppress T cells and other immune elements that would otherwise attack the tumor.

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated genIn the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated genin the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at MoffitIn this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitin lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

Given their similar profiles, Seyedsayamdost and coworkers hypothesized that TDA might exhibit anticancer properties as well, and indeed observed its strong anticancer activity in a screen against 60 different cancer cell lines.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

This technique is able to distinguish cancer cell lines with differing metabolic activities and reveals heterogeneous uptake patterns in neurons, mouse brain tissues and tumor tissues with clear cell - to - cell variations.

Experiments showed that HIFs controlled the production of GSTO1 in breast cancer cells when they were exposed to chemotherapy; if HIF activity was blocked in these lab - grown cells, GSTO1 was not produced.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

In further work, a drug that blocks FAK reduced the formation of mammospheres, or clumps of breast cancer stem cells, showing FAK is important in cancer stem cell activitIn further work, a drug that blocks FAK reduced the formation of mammospheres, or clumps of breast cancer stem cells, showing FAK is important in cancer stem cell activitin cancer stem cell activity.

«Obviously, this information can be used in our efforts to identify drug therapies that kill cancer cells by targeting telomerase activity.»

Professor Aoki says, «By controlling the intercellular transmission of ERK activity in the future, it may be possible to suppress the infiltration of cancer cells.»

In fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cellIn fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cellin the proliferation of cancer cells.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

When the team blocked the activity of L1CAM in cultured human colon cancer cells, the cells» growth slowed dramatically.

Our results suggest that frequent overexpression of Aurora Kinase in cancer may reduce RUNX3 transcription activity, leading to cell division and formation of tumours.

He says that the extracts from their fibroblasts do contain the sticky substance, but that in spalacids it does not seem to play a key role in the animals» natural resistance to cancer or activity against cancer cells in the lab.

In fact, in these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugIn fact, in these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugin these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugin upsetting these cancer cells» activities than many FDA - approved cancer drugs.

When this article was first published on 15 August 2013, it did not explain that HMM - MA in the fibroblasts of Middle East mole rats does not seem to be significant in their resistance to cancer or activity against cancer cells.

UCLA researchers have found that a Chinese herbal regimen called TSY - 1 (Tianshengyuan - 1) increased telomerase activity in normal blood cells but decreased it in cancer cells.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

«Now that we know exactly how changes in EMSY spur cancer cell growth, we can start to design therapies to specifically target that activity and hopefully stop it,» says senior author Douglas Levine, MD, director of the Division of Gynecologic Oncology at NYU Langone and its Perlmutter Cancer Ccancer cell growth, we can start to design therapies to specifically target that activity and hopefully stop it,» says senior author Douglas Levine, MD, director of the Division of Gynecologic Oncology at NYU Langone and its Perlmutter Cancer CCancer Center.

While cancer generally gobbles up fructose, the GLUT5 and metabolic activity of nonmalignant, pre-malignant and malignant breast cancer cells do vary, which is what Rao, Tanasova and their team explored in the Biosensors paper.

«If you can use combination approaches, hitting multiple targets within the cell to reduce the activity of each, and you see a synergistic effect between them, you may be able to overcome some of their harmful effects in HER2 - positive cancer, and perhaps also resistance,» says Tonks.

Using the European Synchrotron Radiation Facility (ESRF), researchers analysed the effects of Organo - Osmium FY26 in ovarian cancer cells — detecting emissions of X-ray fluorescent light to track the activity of the compound inside the cells.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

Vitamin C is known to keep some kinds of cell replication in check, so Benjamin Neel at the New York University School of Medicine probed its effects in mice engineered to have low TET2 activity and a high resulting cancer risk.

This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites.

«Scientists show how cancerous cells evade a potent targeted therapy: Significant antitumor activity was shown in cancers when this therapy was combined with an enzyme.»

Previous studies, however, have also shown that high activity of Lin28a in cancer tissue helps diseased cells grow faster.

This gene has a role in controlling cell division and has been shown to have increased activity in cancers of the breast, stomach and prostate.

The virus, code - named JX - 954, targets two genes involved in cancer cell growth and blood supply, which show increased activity in tumours.

Taken together, the findings suggest that elevating SRC activity beyond the already high levels present in cancer cells further pressures their maximized stress response system and selectively kills them.

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).

Telomerase activity, then, seems to be associated with germinative cells in transition (transient amplifying cells) and cancer cells.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Learning how to control these switches could allow researchers to turn telomerase activity up in aging cells or down in cancer cells.

Interestingly, suppression of Dicer activities is reported to result in promotion of epithelial - mesenchymal transistion and metastatic transformation of cancer cells.