Sentences with phrase «activity in human cells»

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In animals, implanted electrodes were used to measure the activity of individual grid cells directly, but this is not a practical option in humanIn animals, implanted electrodes were used to measure the activity of individual grid cells directly, but this is not a practical option in humanin humans.

The new compounds boost the activity of Sir2 in yeast and of an analogous gene, SIRT1, in human cells.

«We still don't know very much about how individual cells in the brain coordinate the activity of higher - level function that defines us as humans,» he says.

A byproduct of the discovery of RNAi was the finding that although cells in the human body only contain one strand of RNA, they do have micro-RNA — tiny sections of RNA that can act a little like double - stranded RNA and also silence the activity of certain genes.

Working in human lung epithelial cells, researchers used a variety of techniques to show that flu infection increased activity of the PI3K and mTOR pathways and that BEZ235 restored PI3K and mTOR activity to pre-infection levels.

In studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures of cells grown in the laIn studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures of cells grown in the lain cultures of cells grown in the lain the lab.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

«Our study shows, for the first time, in human skin that with increasing age there is a specific decrease in the activity of a key metabolic enzyme found in the batteries of the skin cells.

The researchers used a technique called activity - based protein profiling, which allowed them to screen the molecule's activity against a very large group of enzymes in living human cells.

For the first time, scientists at Newcastle University, UK, have identified that the activity of a key metabolic enzyme found in the batteries of human skin cells declines with age.

It was found that complex II activity significantly declined with age, per unit of mitochondria, in the cells derived from the lower rather than the upper levels, an observation not previously reported for human skin.

When the team blocked the activity of L1CAM in cultured human colon cancer cells, the cells» growth slowed dramatically.

The team realized that, just like the Cas9 family, Cas13d enzymes originating from different bacterial species would vary in their activity, so they ran a screen to identify the best version for use in human cells.

But then ISS itself serves as a home to six microbe - filled humans who stay in orbit for as long as 6 months each and routinely shed skin cells when they exercise, comb their hair, eat, and do other activities that potentially can contaminate their isolated «built environment.»

The device, part of the Lab's iCHIP (in - vitro Chip - Based Human Investigational Platform) project, simulates the central nervous system by recording neural activity from multiple brain cell types deposited and grown onto microelectrode arrays.

Researchers from Turku, Finland, have discovered new information about the mechanisms which maintain gene activity in human embryonic stem cells.

The specificity of this DNA cutting activity has made CRISPR - Cas the darling of gene therapy researchers, who have modified it to make precise changes in the genomes of cultured cells, laboratory animals, and even humans.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell typeIn the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell typein a wide range of mouse and human tissues and cell types.

Bassem Hassan (VIB / KU Leuven): «Since we show that APP and APPL show similar activities in cultured cells, we suspect that APP in the human brain functions in the same manner as APPL in the brain of fruit flies.

But when silenced, labeled DHA was diminished, indicating that human RPE cells can also take up DHA and that the AdipoR1 gene plays a significant role in this activity, too.

The answer to this question may open new routes to target age - dependent alterations of stem cell activity in human disease.

IN THE BEGINNING Early embryos (a four - cell embryo shown) from mice and humans look the same on the outside, but gene activity studies show some big differences under the hood.

To better understand these mechanisms, Too and colleagues infected human motor neuron cells with EV71 and compiled a list of human proteins that showed changes in activity during infection.

Deth reported last year, for example, that in human nerve cells thimerosal blocks a chemical reaction called methylation that is critical to gene activity and that is also disabled by exposure to lead.

Most of the cells in the human body have an internal clock that sets a rhythm for the activities of our organs according to the time of the day.

Studies in the last two decades revealed that telomeres and telomerase have dual functions in suppressing and facilitating tumorigenesis: In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cellin the last two decades revealed that telomeres and telomerase have dual functions in suppressing and facilitating tumorigenesis: In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cellin suppressing and facilitating tumorigenesis: In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cellIn the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cells.

University of Bonn researchers have discovered a new method to measure the activity of brown fat cells in humans and mice.

In today's issue of Science Translational Medicine, he and his colleagues present a more efficient way of finding such new uses for old drugs: by bringing together data on how diseases and drugs affect the activity of the roughly 30,000 genes in a human celIn today's issue of Science Translational Medicine, he and his colleagues present a more efficient way of finding such new uses for old drugs: by bringing together data on how diseases and drugs affect the activity of the roughly 30,000 genes in a human celin a human cell.

Joanna Wysocka and her colleagues at Stanford University in California made the unexpected find while they were analysing gene activity in 3 - day - old human embryos, which are bundles of eight cells.

In another experiment, blocking the activity of inflammatory cytokines in the presence of DENV NS1 did not prevent disruption of human cell layers similar to those found in the lining of blood vesselIn another experiment, blocking the activity of inflammatory cytokines in the presence of DENV NS1 did not prevent disruption of human cell layers similar to those found in the lining of blood vesselin the presence of DENV NS1 did not prevent disruption of human cell layers similar to those found in the lining of blood vesselin the lining of blood vessels.

Thus, high ALKBH1 activity can globally decrease the amount of proteins made in a cell, as the researchers observed in a human cell line with abnormally high levels of ALKBH1.

Now, however, a team of researchers led by Yu - Hua Tseng, Ph.D., Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, has created cell lines of human brown and white fat precursor cells that will help investigators to pick apart the factors that drive the development and activity of each type of cell.

One CUMC team, led by Tom Maniatis, PhD, the Isidore S. Edelman Professor and chair of biochemistry & molecular biophysics, will construct an atlas of gene activity of all cells in the human spinal cord.

Lack of telomerase activity in human mesenchymal stem cells.

UC San Francisco researchers have identified cells» unique features within the developing human brain, using the latest technologies for analyzing gene activity in individual cells, and have demonstrated that large - scale cell surveys can be done much more efficiently and cheaply than was previously thought possible.

A team at Cold Spring Harbor Laboratory (CSHL) led by Professor and HHMI Investigator Leemor Joshua - Tor of the W. M. Keck structural biology laboratory today publishes a paper in the journal Cell Reports that defines the critical differences between the human Argonautes that lead to their differences in activity.

We need to modify brain activity in humans to test whether particular brain regions contribute to perception and behavior, and we need to do the same in animals to modify activity in particular cell - types to understand the molecular basis of these processes.

N - acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2 / 9 activity in early human pregnancy.

TGF - beta 1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice.

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells, reports a new study, published in PNAS.

The in vitro activity and specificity of human endothelial cell - specific promoters in porcine cells.

The molecules central to this balancing act, H3K4me3 and H3K27me3, are among the so - called epigenetic modifications that influence the activity patterns of genes in both human embryonic stem (ES) cells and mature human adult cells.

This team plans to conduct the first human clinical trial combining these two therapeutic strategies (which have been tested separately and have shown activity in reducing HIV in humans), with the expectation that a boosted innate immune system empowered with unique antibodies to target HIV - infected cells will achieve greater reductions in HIV than observe previously.

The aim of the present study was to evaluate glucose transport and GS activity in human satellite cell cultures established from type 2 diabetic and control subjects.

Effect of preculturing human satellite cell cultures in increasing concentrations of insulin on the activity constant A0.5 of GS.

Human satellite cell cultures were exposed for 4 days to different insulin conditions, and the GS activity was measured at 0.1 and 10 mmol / l G6P under basal and after acute insulin stimulation (Ins.

Effect of preculturing human satellite cell cultures in increasing concentrations of insulin on the basal and insulin - stimulated glucose transport activity in cultures of human myofibers.

Pim - 3, a Proto - Oncogene with Serine / Threonine Kinase Activity, Is Aberrantly Expressed in Human Pancreatic Cancer and Phosphorylates Bad to Block Bad - Mediated Apoptosis in Human Pancreatic Cancer Cell Lines

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

«To then determine how disrupting the gene might play out in the context of disease, we chemically knocked out the activity of SLC16A11 in human liver cells,» explains co-first author Victor Rusu, a former Harvard graduate student at Broad now at Jnana Therapeutics.