Sentences with phrase «activity of amyloid»

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.

With its report, the Harvard / MGH - led team is the first to show antimicrobial activity of amyloid - β in animals.

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

Not exact matches

«Because brain cells release amyloid beta during activity, we think if the brain cells can't rest the way they're supposed to and get that deep sleep, they produce a relative excess of amyloid,» Dr. Yo - El Ju of Washington University, an author of that study, told Reuters.

«The amyloid hypothesis became such a strong scientific orthodoxy that it began to be accepted on the basis of faith rather than evidence,» says Zaven Khachaturian, president of the non-profit campaign Prevent Alzheimer's Disease 2020, and former coordinator of Alzheimer's - related activities at the US National Institutes of Health.

Up to now researchers thought that the astrocytes migrated towards the amyloid plaques and devoured them, so that reinforcing their activity could be a good remedy against development of the disease.

«People with this gene mutation usually get Alzheimer's at around age 70 because of the buildup of amyloids due to the reduced activity of the protective enzyme,» says Tanzi.

In 78 brain regions, they factored in the pattern of amyloid concentration, glucose metabolism, cerebral blood flow, functional activity and brain atrophy.

For this study, 10 subjects with Alzheimer's underwent PET following the injection of three radiotracers: fluorine - 18 fluorodeoxyglucose (F - 18 FDG), which images regional metabolic activity; carbon - 11 Pittsburgh compound B (C - 11 PiB), which has an affinity for amyloid plaques; and F - 18 AV - 1451, an emerging imaging agent that binds to tau in the brain.

A new imaging study in living Alzheimer's patients is combining three methods of positron emission tomography (PET) to measure the orchestration of amyloid, tau and metabolic activity in the brain.

The light seemed to boost the activity of cells that clear amyloid, and cut amyloid production (Nature, DOI: 10.1038 / nature20587).

Mcc is a small — molecular - weight bacteriotoxin, with activity regulated in vivo by aggregation into amyloid fibrils at the stationary phase of the bacterial culture (Bieler et al., 2005; Shahnawaz et al., 2017).

«The activity of the microglia is stimulated by dying brain cells, not by the deposits of amyloid proteins, called plaques, which also occur in Alzheimer's disease,» Haass notes.

The results were remarkably positive, with the reduction in BACE1 activity not only stalling the development of amyloid plaques in the mice, but actually removing the deposits that had already formed.

San Diego, Calif. (Embargoed until 1:15 PM on Wednesday, June 15)-- Positron emission tomography (PET) with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer's patients.

The accumulation of amyloid beta in the brain has also been linked to this imbalance between excitatory and inhibitory activity in the brain.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

He has demonstrated that amyloid - beta — together with tau, another protein that accumulates in the brains of Alzheimer's patients — disrupts brain - network activity.

It also showed that their immune cells were increasing noticeably in both size and activity, suggesting that these cells were cleaning up the high levels of amyloid proteins.

«For instance, efforts to block the infection - enhancing activity of these semen amyloids for STD prevention must now consider the potential effects of such interventions on sperm quality and immune recognition of male antigens.»

These studies revealed that loss of NEU1 activity was associated with a build - up in lysosomes of the amyloid precursor protein (APP), which they identified as a natural target of the enzyme.

The study suggests that «a slow - gamma deficit might be part of this [Alzheimer's disease] pathogenesis [and that] manipulating slow - gamma activity... could be a new way to suppress amyloid - β production and increase amyloid - β clearance,» Huang added.

«When we looked specifically at the level of lifetime learning, we found that carriers of the APOE4 gene who had higher education and continued to learn through middle age had fewer amyloid deposition on imaging when compared to those who did not continue with intellectual activity in middle age,» she said.

«It is possible those who did not continue intellectual activity in middle age did so because they had higher levels of amyloid plaques,» she said.

Evidence shows that green tea may possess potent activities of neuroprotection and amyloid precursor protein processing leading to cognitive enhancement.

One way the brain eliminates the amyloid - beta typically produced by cell activity in the brain is by moving it to the spinal fluid for disposing of.

Enhancing valuable AMPK activity can improve memory while suppressing the formation of beta - amyloid plaque and tau tangles — both indicators of Alzheimer's disease — and can cause an additional 20 percent increase in lifespan.

Reduced metabolic activity of brain cells and neurons means less brain activity and a decreased ability of the brain to clear abnormal structures like the beta - amyloid plaques associated with Alzheimer's disease.

These may include accumulation of B - amyloid, declining neurotransmitter activities, or increased activity of monoamine oxidase - B, an enzyme that may catalyze the metabolism of dopamine.1